In recent years, the dysfunction of the haemostatic system in relation to the clinical complications from arterioscleroses and cardiovascular diseases has become more recognised. Blood coagulation and fibrinolysis comprise two important physiological systems, which are regulated by a balance between activators and inhibitors. Activation of blood coagulation is associated with accelerated clot f...

T HREE TYPES of evidence exist that support an important relationship between blood coagulation and tumor homeostasis: clinical, histologic, and pharmacologic. Clinical and laboratory evidence focuses on the well known propensity of patients with certain forms of cancer to develop thromboembolic disease (TED) and/or disseminated intravascular coagulation (DIC), commonly observed following rapid...

Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis Platelet-mediated primary haemostasis and blood coagulation have evolved as important defence mechanisms against bleeding. The formation of the platelet plug provides the initial occlusion of the vascular lesion. This is temporally co-ordinated with the activation of the coagulation system, which occurs in resp...

have indicated that normal cell-free human plasma contains some factors which are deficient in hemophilia. There is evidence that by the parenteral administration of derivatives of normal cell-free plasma in hemophilia, the coagulation defect can be modified toward normal. The present communication reviews some of the older work on this subject and presents new evidence accumulated during the p...

This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro, distinct from Hageman factor and Fletcher factor deficiencies. Coagulation studies in a 50-yr-old French woman without bleeding tendency revealed the following results: whole-blood clotting time in glass tubes and activated partial thromboplastin time with kao...

This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro, distinct from Hageman factor and Fletcher factor deficiencies. Coagulation studies in a 50-yr-old French woman without bleeding tendency revealed the following results: whole-blood clotting time in glass tubes and activated partial thromboplastin time with kao...