The paper briefly outlines the business modeling language GRAPES-BM and the CASE tool GRADE-BM based on it. The business modeling language GRAPES-BM is a semiformal graphic language for modeling and simulation of complicated business systems (production processes, offices, information systems). GRAPES-BM relies on such basic concepts as task, event, performer, triggering condition etc. and cont...

While cadaveric vertebral bodies (VB) have long been proposed as a suitable source of bone marrow (BM) for transplantation (BMT), they have rarely been used for this purpose. We have infused VB BM immediately following whole organ (WO) transplantation to augment donor cell chimerism. We quantified the hematopoietic progenitor cell (HPC) content of VB BM as well as BM obtained from the iliac cre...

To develop an effective therapeutic strategy for cardiac regeneration using bone marrow mesenchymal stem cells (BM-MSCs), the primary mouse BM-MSCs (1(st) BM-MSCs) and 5(th) passage BM-MSCs from β-galactosidase transgenic mice were respectively intramyocardially transplanted into the acute myocardial infarction (AMI) model of wild type mice. At the 6(th) week, animals/tissues from the 1(st) BM-...

Positron emission tomography using radiolabeled amino acid (PET-AA) appears to be promising in distinguishing between recurrent tumour and radionecrosis in the follow-up of brain metastasis (BM). The amino acid transporter LAT1 and its cofactor CD98, which are involved in AA uptake, have never been investigated in BM. The aim of our study was to determine and compare the expression of LAT1 and ...

Despite organizations’ substantial investments in information systems and information technology, the successful realization of appropriate benefits is still often considered a major organizational challenge. Beyond traditional project management dimensions, such as time, cost, and quality, BM emphasizes the need to identify, plan, realize, and review benefits, particularly by means of business...

We present a bit rate maximising per-tone equalisation (BM-PTEQ) cost function that is based on an exact subchannel SNR as a function of per-tone equaliser in discrete multitone (DMT) systems. We then introduce the proposed BM-PTEQ criterion whose derivation for solution is shown to inherit from the methodology of the existing bit rate maximising time-domain equalisation (BM-TEQ). By solving a ...

The mammalian tachykinins mediate crosstalk within the neural-immune-hematopoietic axis. Hematopoiesis occurs in the adult bone marrow (BM) and it is described as the method by which the immune system is replenished by a finite number of hematopoietic stem cells (HSC). These cells are found in the BM close to the endosteum where the oxygen level is the lowest. The BM is also resident to mesench...