BACKGROUND The aim of the present study was to prospectively evaluate the diagnostic utility of B-type natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) measurements for the detection of cardiac structural disease in asymptomatic patients with systemic arterial hypertension and to test the hypothesis that the 2 analytes are equally useful in this clinical setting. METHODS We stu...

BACKGROUND The B-type or brain natriuretic peptides (BNP) and the amino-terminal probrain natriuretic peptide (NT-proBNP) are good markers of prognosis and diagnosis in chronic heart failure (HF). It is unclear, however, whether differences in their biological characteristics modify their clinical correlates and prognostic performance in HF. This work aimed to provide a direct comparison of the...

AIMS Amino-terminal portion of pro-B-type natriuretic peptide (NT-pro-BNP) is a valuable diagnostic and prognostic marker in congestive heart failure (CHF). In CHF patients, elevation of natriuretic peptide levels correlate with decreased left ventricular (LV) ejection fraction (EF) and increased left atrial (LA) volumes, but a correlation with LA function that is a determinant of haemodynamic ...

The purpose of this study was to develop prognostic models for heart failure in dogs with dilated cardiomyopathy (DCM). The prospective study included 26 dogs with DCM and 58 healthy dogs. The ervation time median was 250 days (1-600 days). All the dogs were clinically examined, had echocardiography, electrocardiography, and morphological and biochemical blood sampling. Twenty four deaths were ...

A large number of experimental studies have suggested that hypoxia may be a potent stimulus for the myocardial synthesis and release of Atype natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) [1]. However, these studieshaveevaluatedeither theeffectofhypoxiaonANP and/orBNPproduction in isolated cardiomyocytes [2,3], isolatedperfused hearts [4,5], or animals [5,6], or on the circulat...

C ardiovascular disease is the most frequent cause of death in patients with diabetes (1). It is difficult to evaluate the cardiovascular status of patients with diabetes because of complex symptomology, evidence of silent ischemia, and subclinical cardiac disease. Brain (B-type) natriuretic peptide (BNP) and the NH2terminal fragment of its prohormone (NT-proBNP) are novel biomarkers, which are...

IntroductionAnthracyclines are commonly used anticancer drugs because of their proven potency but cardiotoxicity represents their most devastating effect .The present study was undertaken to explore the role of biomarkers (NT pro BNP & troponin I) for the detection of chemotherapy induced cardiotoxicity. MethodsTwenty two patients of malignancy who previously underwent anthracycline chemotherap...

The aim of the present article was to evaluate the association of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with contrast-induced nephropathy (CIN) and long-term outcomes in patients with chronic kidney disease (CKD) and relative preserved left ventricular function (LVF) undergoing percutaneous coronary intervention (PCI). We prospectively enrolled 1203 consecutive patients with CK...

BACKGROUND The inferior vena cava (IVC) diameter and degree of inspiratory collapse are used as echocardiographic indices in the estimation of right atrial pressure. Brain-natriuretic peptides (BNPs) are established biomarkers of myocardial wall stress. There is no information available regarding the association between the IVC diameter and BNPs in patients with heart failure and various degree...