OBJECTIVES To compare serum markers of bone formation with the urinary excretion of pyridinium crosslinks (PYR) as a possible measure of bone and cartilage degradation which would detect changes in bone metabolism in patients with ankylosing spondylitis (AS) and to relate them to influences of inflammatory disease activity, and to treatment. METHODS In 62 patients with AS, serum osteocalcin, ...

The purpose of this study was to investigate the association between coffee consumption and bone status (bone mineral density and bone metabolism-related markers) according to calcium intake level in Korean young adult males. Healthy and nonsmoking males (19-26 years, n = 330) participated in this study. Anthropometric measurements, dietary habits, and nutrient intakes were surveyed. Bone statu...

BACKGROUND: Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone metabolic markers. Therefore aim of this study was to evaluate the usefulness of the determination of bone metabolic markers aminoterminal propeptide of type I procollagen (PINP,...

The impact of obesity upon bone metabolism is controversial since both beneficial or harmful effects have been reported. Bone remodeling modulated by the central nervous system through cytokines, hormones and neuromodulators. present study aimed to evaluate evoked bilateral retroperitoneal white adipose tissue (rWAT) denervation (Dnx) mineral in an experimental model rats. Male Wistar rats were...

Bone tissue is continuously remodeled by bone cells and maintenance of its mass relies on the balance between the processes of resorption and formation. We have reported the expression of numerous scavenger receptors, namely scavenger receptor (SR) class B type I and II (SR-BI and SR-BII), and CD36, in bone-forming osteoblasts but their physiological roles in bone metabolism are still unknown. ...

OBJECTIVE Acromegaly is characterized by a persistent hypersecretion of GH and provides information on long-term effects of GH on bone metabolism. The aim of this study was to examine the effect of gonadal status and disease activity on bone metabolism in active acromegaly. METHODS Seventy-three consecutive patients with active acromegaly: 40 women and 33 men (50 +/- 13 (mean +/- s.d.) and 49...

INTRODUCTION: Hemodialysis (HD) patients often have a characteristic abnormality of bone metabolism that is known as renal osteodystrophy (ROD). ROD in HD patients with diabetes mellitus is characterized by lower plasma parathyroid hormone levels and a lower bone turnover rate than nondiabetic controls [1]. Bone remodeling is an ongoing cyclical process characterized by two activities: bone for...

OBJECTIVES Nociceptors are expressed at peripheral terminals of neurons. Recent studies have shown that TRPV1, a nociceptor, is expressed in bone tissue and regulates bone metabolism. We have demonstrated that a TRPV1 antagonist improved pain-like behavior in ovariectomized (OVX) mice. The aim of this study was to determine whether nociceptors, including TRPV1, acid-sensing ion channel (ASIC) a...

The present study aimed to investigate the protective and therapeutic effect of Exenatide on osteoporosis induced by ovariectomy in female Wister rats. results this showed that administration at a dose 10 mg/kg daily for 4 months led reduction symptoms ovariectomized rats, which was manifested changes serum levels bone metabolism markers (a significant increase concentration calcium, phosphorou...