We have investigated approaches to induce graft-versus-leukemia (GVL) effect in autologous bone marrow transplantation (ABMT) without graft-versus-host disease to improve survival and cure in leukemia. The present study shows that bone marrow transplantation (BMT) using syngeneic bone marrow activated with interleukin-2 (ABM) for 24 hours in vitro, followed by interleukin-2 (IL-2) therapy, was ...

These studies tested the hypothesis that human herpesvirus 6 (HHV-6) can cause posttransplant bone marrow (BM) suppression in BM transplant (BMT) patients. Fifteen adult patients who received T-lymphocyte-depleted, allogeneic BM transplants and who developed posttransplant BM suppression were studied. Detailed chart reviews were used to divide the patients into two groups: (1) those with diagno...

Bone marrow transplantation (BMT) is often followed by significant morbidity and mortality due to protracted immunodeficiency. We have hypothesized that the bone marrow-ablative regimen may delay the recovery of normal immune function following transplantation by impairing the interaction of host endothelial cells with circulating graft-derived lymphocytes. This report compares the relative eff...

Administration of agonistic monoclonal antibodies or recombinant cytokines is a potential approach to enhance antitumor immunity in bone marrow (BM) transplant recipients, but is complicated by toxicity due to proinflammatory cytokine-mediated vital organ damage. We used a murine syngeneic bone marrow transplant (BMT) model, in which administration of anti-CD40 antibody early after BMT results ...

over time with transplant is not warranted. A portion of the sample REFERENCES did stay the same or better, and half were in the average range of 1. Peters C, Balthazor M, Shapiro EG, King RJ, Kollman C, intelligence at outcome on the Stanford Binet Intelligence Scale or Hegland JD, Henslee-Downey J, Trigg ME, Cowan MJ, Sanders J, McCarthy Scales of Children’s Abilities. We also note that, in t...

Autoiogous bone marrow transplantation (BMT) ~ is being evaluated at several medical centers as an alternative approach to aliogeneic BMT for the t rea tment of acute lymphoblastic leukemia (ALL) patients who do not have matched sibling donors (1, 2). A major limitation o f autologous B M T is the likely presence o f residual leukemia in the remission marrow (2). This difficulty makes ex vivo p...

Case Report A previously well 10-year-old Vietnamese boy with exanthematous fever, jaundice (Alanine aminotransferase 688 U/L, Aspartate aminotransferase 340 U/L) and pancytopoenia (Haemoglobin 4.2 g/dL, WBC 1.7 x 109/L, and platelets < 20 x 109/L) developed grade 4 hepatic encephalopathy at 10 weeks of illness. Extensive workup failed to reveal the aetiology. At 11 weeks of illness, a liver tr...

During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bone marrow that has been depleted of mature T lymphocytes to prevent graft v hos...

Non-myeloablative bone marrow transplantation (NM-BMT) is a newly developed therapeutic strategy for malignant and non-malignant hematological diseases, as well as immunotherapy-responsive solid tumors. The graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect is the major therapeutic effect of this procedure, which also decreases transplant-related mortality (TRM) while remaining rela...