نتایج جستجو برای: bone neoplasms
تعداد نتایج: 762185 فیلتر نتایج به سال:
Paget’s disease of bone is a common metabolic disorder, which is in most cases diagnosed on the basis of its radiographic findings. Its primary bone alterations and subsequent complications constitute a complex range of pathologic pictures, which may pose diagnostic difficulties upon histologic examination. This article illustrates the spectrum of pathologic features of Paget’s disease of bone ...
OBJECTIVES Flow cytometry immunophenotyping has been suggested as an adjunctive technique in the evaluation of myeloid malignancies, especially in the myelodysplastic syndromes. However, its use has been limited due to complexity and cost restraints. The goal of this study is to attempt a simpler approach to flow cytometry immunophenotyping in myeloid neoplasms. METHODS We analyzed bone marro...
Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and radiation oncologists, and surgeons and radiologists with demonstrated expertise in the management of these tumors. Long-term surveillance and follow-u...
Introduction Chronic recurrent mutifocal osteomyelitis (CRMO) (OMIM-number-259680), a rare form of autoinflammatory disease of the bone marrow of unknown aetiology, which takes a sub-acute course. First described in 1972 by Gideon et al, CRMO is primarly a diagnosis of exclusion as suggested by negative bone biopsy for neoplasms and negative bone culture to rule out infectious causes. In our ca...
Primary vascular neoplasms of bone are rare and have a poor prognosis. Angiosarcoma of bone originates in vascular endothelial cells within bone tissue. Patients may present with unifocal or multifocal osseous disease. The most commonly involved bones are femur and tibia, followed by pelvis, vertebral column and bones of the upper limb. Here we present a 72-year-old male patient who had primary...
Spinal tumors consist of a large spectrum of various histologic entities. Multiple spinal lesions frequently represent known metastatic disease or lymphoproliferative disease. In solitary lesions primary neoplasms of the spine should be considered. Primary spinal tumors may arise from the spinal cord, the surrounding leptomeninges, or the extradural soft tissues and bony structures. A wide vari...
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with use different drugs administered in treatment malignant neoplasms or metastases and antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism action is to prevent activation RANK receptor on surface osteoclasts, jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) rare neoplasm charac...
An aneurysmal bone cyst involving the rib is very rare. Forty-four cases have been reported in the literature. Primary neoplasms of the ribs are uncommon and malignant tumours are significantly more common than benign tumours in this location. The condition is a rare benign, progressive bone tumour. The aetiology and natural history are unknown. The Authors report the case of a 38-year-old man ...
Background: The important of angiogenesis for the progressive growth and viability of solid tumors is well established. Only few data are available for hematologic neoplasms. Materials and Methods: To investigate the role of angiogenesis in the acute myloid leukemia (AML) bone marrow biopsies from 30 adults with newly diagnosed, untreated AML(day 0) were evaluated. Further studies were done aft...
Philadelphia-negative classical myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The 2016 revision of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes new criteria for the diagnosis of these disorders. Somatic mutations in the 3 driver genes, that is, JAK2, CALR, and MPL, represe...
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