A unique 'second' niche for follicular B cells has been described in the extravascular compartment of the bone marrow surrounding vascular sinusoids. The occupancy of this niche by B cells presumably evolved to facilitate humoral immune responses to blood-borne pathogens. B cells appear to be sustained in this niche by bone marrow dendritic cells and are lost from this compartment in certain mu...

E ase of administration, accuracy, and convenience are among the hallmark characteristics of insulin pens. These devices, which have gained popularity over the past 10 years, are designed to be used multiple times for a single person, using a new needle for each injection. Unfortunately, reports of themisuse of insulin pens also have been growing. Backflow of blood and other biologic material i...

Vector-borne pathogens cause enormous suffering to humans and animals. Many are expanding their range into new areas. Dengue, West Nile and Chikungunya have recently caused substantial human epidemics. Arthropod-borne animal diseases like Bluetongue, Rift Valley fever and African horse sickness pose substantial threats to livestock economies around the world. Climate change can impact the vecto...

Mosquito-borne diseases cause significant public health burden and are widely re-emerging or emerging. Understanding, predicting, and mitigating the spread of mosquito-borne disease in diverse populations and geographies are ongoing modelling challenges. We propose a hybrid network-patch model for the spread of mosquito-borne pathogens that accounts for individual movement through mosquito habi...

Mosquito-borne pathogens remain a threat to public health in Australia. The activity of dengue and chikungunya viruses has increased across South-East Asia and the Pacific region in recent years, and the number of travellers returning to Australia infected with mosquito-borne pathogens has steadily grown.1 Annual notifications of endemic mosquito-borne disease resulting from infection with Ross...