نتایج جستجو برای: bracelet cyclotides
تعداد نتایج: 428 فیلتر نتایج به سال:
Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides. In particular, it is difficult to apply these methods to cyclic and cysteine-stabilized peptides since they exhibit reduced amenability to chemical modification a...
Antimicrobial peptides (AMPs) are essential components of innate immunity in all living organisms, and these potent broad-spectrum antimicrobials have inspired several antibacterial development programs in the past 2 decades. In this study, the development of resistance to the Gram-negative bacterium-specific peptide cycloviolacin O2 (cyO2), a member of the cyclotide family of plant miniprotein...
The size of a mobile device limits its input capabilities. To address this problem, we propose the Interactive Bracelet, an input device worn on the wrist that brings bimanual gestures to the mobile or ubiquitous computer. We describe example scenarios that illustrate how we imagine the device could be used, and we discuss how the device can be implemented and what sensors and actuators should ...
Several members of the Rubiaceae and Violaceae plant families produce a series of cyclotides or macrocyclic peptides of 28-37 aa with an embedded cystine knot. The cyclic peptide backbone together with the knotted and strongly braced structure confers exceptional chemical and biological stability that has attracted attention for potential pharmaceutical applications. Cyclotides display a divers...
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