BACKGROUND Using the techniques of molecular biology, recent experimental studies have shown that cerebral ischemia induces a variety of changes in gene expression in the brain. SUMMARY OF REVIEW During the early postischemic stages, protein synthesis in the brain is generally suppressed, but specific genes are expressed and their corresponding proteins may be synthesized, such as immediate-e...

The cerebral endothelium is an active interface between blood and the central nervous system. In addition to being a physical barrier brain, also actively regulates metabolic homeostasis, vascular tone permeability, coagulation, movement of immune cells. Being part blood–brain barrier, endothelial cells brain have specialized morphology, physiology, phenotypes due their unique microenvironment....

Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...

introduction: development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. blood brain barrier (bbb) opening is an important part of edema named as vasogenic brain edema. in this study, quantitative alterations of bbb permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. methods: two groups of male rats (ischemic and sh...

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

Introduction: Pixel value in computed tomography (CT) gives the average linear attenuation coefficient of the scanned material in the path of the x-ray beam, being normalized to that of water. It is known that attenuation coefficient or HU value is a function of the chemical characteristic of the material and of the x-ray energy. The CT image shows the HU value by a shade of gr...

The study determines whether hyperhomocysteinemia (risk factor of brain ischemia) alone or in combination with ischemic preconditioning (IPC) affects the ischemia-induced changes in gene expression of secretory pathways Ca(2+)-ATPase (SPCA1). Hyperhomocysteinemia was induced by subcutaneous administration of homocysteine (Hcy; 0.45 µmol/g body weight) twice a day at 8 h intervals for 14 days. R...

BACKGROUND Preconditioning to ischemia is a phenomenon whereby a brief episode of sublethal ischemia and other nonlethal stressors produce protection against a subsequent detrimental ischemic insult. As mitochondrial dysfunction is related to necrotic and apoptotic neuronal death after cerebral ischemia, the authors examined if ischemic preconditioning is capable of inducing mitochondrial toler...

oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. as the antioxidant effects of some species of pistacia have been reported, the protective effects of pistacia vera l. gum extract (0.1-0.5 g/kg) on oxidative damage following cerebral ischemia were studied in rats. ischemia was induced using four-vessel occlusion model and evaluated using measurement of m...