نتایج جستجو برای: brb

تعداد نتایج: 533  

2015
Claudia Niccolai Emilio Portaccio Benedetta Goretti Bahia Hakiki Marta Giannini Luisa Pastò Isabella Righini Monica Falautano Eleonora Minacapelli Vittorio Martinelli Chiara Incerti Ugo Nocentini Giuseppe Fenu Eleonora Cocco Maria Giovanna Marrosu Elisa Garofalo Ferdinando Ivano Ambra Maurizio Maddestra Marilena Consalvo Rosa Gemma Viterbo Maria Trojano Nunzia Alessandra Losignore Giovanni Bosco Zimatore Erika Pietrolongo Alessandra Lugaresi Lorena Pippolo Marco Roscio Angelo Ghezzi Debora Castellano Sergio Stecchi Maria Pia Amato

BACKGROUND Recently, a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been developed as an international and standardized brief cognitive test, which is easily performed in everyday clinical practice for neuropsychological assessment in multiple sclerosis (MS). However, we need to gather more information about this tool compared to other neuropsychological batterie...

Journal: :Circulation 2005
Demetra D Christou Pamela Parker Jones Jens Jordan André Diedrich David Robertson Douglas R Seals

BACKGROUND Short-term and tonic regulation of arterial blood pressure (BP) differ in premenopausal women and men of similar age. The autonomic nervous system (ANS) plays a critical role in BP regulation. METHODS AND RESULTS To test the hypothesis that women have lower tonic ANS support of BP (reduction in intra-arterial BP during acute ganglionic blockade [GB] with intravenous trimethaphan) a...

Journal: :Nucleic acids research 1982
H. Baumlein U. Wobus S. A. Gerbi F. C. Kafatos

A clone derived from the Balbiani ring b (BRb) gene of Chironomus thummi has been used to study the internal organization of that gene. Much of the gene consists of approximately 80 copies of a ca. 300 bp repeat unit, which are tandemly organized. The BRb clone contains a major part of that unit (242 bp). Sequence analysis shows that approximately 60% of the unit corresponds to short, tandemly ...

2017
Steve Oghumu Bruce C. Casto Jennifer Ahn-Jarvis Logan C. Weghorst Jim Maloney Paul Geuy Kyle Z. Horvath Claire E. Bollinger Blake M. Warner Kurt F. Summersgill Christopher M. Weghorst Thomas J. Knobloch

Oral cancer continues to be a significant public health problem worldwide. Recently conducted clinical trials demonstrate the ability of black raspberries (BRBs) to modulate biomarkers of molecular efficacy that supports a chemopreventive strategy against oral cancer. However, it is essential that a preclinical animal model of black raspberry (BRB) chemoprevention which recapitulates human oral...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2015
Shinobu Fujii Chikako Setoguchi Kouichi Kawazu Ken-ichi Hosoya

Systemically administered pravastatin effectively treats diabetic retinopathy without central nervous system side effects. The efflux transport mechanism of pravastatin from the brain has already been clarified. In this study, the influx of pravastatin across the blood-retinal and blood-brain barriers (BRB and BBB) and the efflux of pravastatin from the retina were investigated using rats. Prav...

2010
Ermelindo C. Leal João Martins Paula Voabil Joana Liberal Carlo Chiavaroli Jacques Bauer José Cunha-Vaz António F. Ambrósio

OBJECTIVE Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy in the last decades, but its mechanisms of action are not elucidated. CaD is able to correct the excessive vascular permeability in the retina of diabetic patients and in experimental diabetes. We investigated the molecular and cellular mechanisms underlying the protective effects of CaD against the increa...

2010
Elie Motulsky Philippe Koch Sarah Janssens Maité Liénart Anne-Marie Vanbellinghen Nargis Bolaky Chi-Chao Chan Laure Caspers Maria-Dolores Martin-Martinez Heping Xu Christine Delporte François Willermain

PURPOSE Blood-retinal barrier (BRB) breakdown and retinal edema are major complications of autoimmune uveitis and could be related to deregulation of aquaporin (AQP) expression. We have therefore evaluated the expression of AQP1 and AQP4 on BRB cells during experimental autoimmune uveitis (EAU) in mice. METHODS C57Bl6 mice were immunized with interphotoreceptor retinoid-binding protein (IRBP)...

Journal: :Investigative ophthalmology & visual science 1997
S D Bamforth S L Lightman J Greenwood

PURPOSE To examine, by ultrastructural analysis, the effect of the proinflammatory cytokine interleukin-1 beta (IL-1 beta) on the integrity of the rat retina and blood-retinal barrier (BRB) and to investigate the site of barrier leakage and the path of leukocyte infiltration into the retina. METHODS After a single injection of IL-1 beta into the vitreous of the Lewis rat, leukocyte recruitmen...

Journal: :Investigative ophthalmology & visual science 2007
Jyotirmoy Kusari Sheila Zhou Edwin Padillo Kenneth G Clarke Daniel W Gil

PURPOSE To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats. METHODS Based on basal body weight and blood glucose, Brown Norway (BN) rats were divided into three groups. One group of rats was treated with vehicle (VEH), and the other two groups were treated ...

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