Methods An initial individual session was conducted by one of the authors (HS) to assess medical conditions and review life stressors and symptom progression in order to identify linkages between stressors and symptoms. The treatment program consisted of 4 weekly small group 2-hour sessions. Components included readings, writing about emotions, mindfulness and emotional awareness exercises (on ...

IMPORTANCE Despite the prevalence and the functional, psychological, and economic impact of chronic pain, few intervention studies of treatment of chronic pain in veterans have been performed. OBJECTIVE To determine whether a stepped-care intervention is more effective than usual care, as hypothesized, in reducing pain-related disability, pain interference, and pain severity. DESIGN, SETTIN...

PURPOSE Abnormal regulation of the hypothalamic-pituitary-adrenal axis and diurnal cortisol rhythms are associated with several pain and chronic inflammatory conditions. Chronic stress may have a role in the disorder of chronic prostatitis/chronic pelvic pain syndrome related to initiation or exacerbation of the syndrome. We tested the hypothesis that men with chronic pelvic pain syndrome have ...

OBJECTIVE Assess the efficacy of duloxetine 60/120 mg (N = 162) once daily compared with placebo (N = 168) in the treatment of patients with fibromyalgia, during six months of treatment. METHODS This was a phase-III, randomized, double-blind, placebo-controlled, parallel-group study assessing the efficacy and safety of duloxetine. RESULTS There were no significant differences between treatm...

OBJECTIVES This study evaluated the prevalence and correlates of aberrant drug-taking behaviors in two populations: patients with HIV-related pain and a history of substance abuse (n = 73) and patients with cancer pain and no history of substance abuse (n = 100). METHODS All patients completed a Drug-Taking Behaviors Interview, the Brief Symptom Inventory (BSI), Brief Pain Inventory (BPI), Me...

AIM OF THE STUDY To compare analgesia and adverse effects during oral morphine and oxycodone and transdermal fentanyl and buprenorphine administration in cancer patients with pain. PATIENTS AND METHODS Cancer patients treated at home and in outpatient clinics with severe pain (numerical rating scale score 6-10) fail to respond to non-opioids and/or weak opioids. All patients were randomized t...

INTRODUCTION Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain. We investigated the efficacy and tolerability of a dose-escalation combination therapy with prolonged-release oxycodone/naloxone (OXN-PR) and pregabalin in patients with non-small-cell lung cancer and sev...

9 based on reducing tissue levels of inflammatory mediators. Thus, the effective debridement of the infected root canal system, combined with incision for drainage and occlusal reduction if indicated, provides predictable pain reduction strategies in endodontic emergency patients. Antiinflammatory drugs (NSAIDs) are commonly used in the management of endodontic pain. NSAIDs reduce pain and infl...

Background and purpose Myelin oligodendrocyte glycoprotein-antibody–associated disease (MOGAD) is an inflammatory autoimmune condition of the central nervous system. However, data on pain depression have remained scarce. The aim this study was to assess features chronic as well their impact health-related quality life (hr-QoL) in MOGAD. Methods Patients with MOGAD were identified Neuromyelitis ...

Chronic pain and obesity are significant public health concerns in the United States associated with significant levels of health-care expenses and lost productivity. Previous research suggests that obesity is a risk factor for chronic pain, mainly due to excessive weight placed on the joints. However, the obesity-pain relationship appears to be complex and reciprocal. Little work to date has f...