Pieter van Dillewijn,1 Hideaki Nojiri,2 Jan Roelof van der Meer,3 and Thomas K. Wood4,5,6* Department of Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), E-18008 Granada, Spain. Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan. Department of Fundamental Microbiology, University of Laus...

Currently there are relatively few antiviral therapeutics, and most which do exist are highly pathogen-specific or have other disadvantages. We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces apoptosis in cells containing viral dsRNA, rapidly killing infected cells without harming uninfect...

A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital footprints recorded on smart sensors). Capability for modeling information fro...

Thanks to researches and the development of integrated optics devices for optical applications in the telecommunications, relatively cheap sources and detectors of optical radiation that can be used in the design of planar optical sensors [1, 2]. One of the commonly used sensor systems is the differential interferometer, based on planar waveguides [3]. In the analyzed system propagates a mode f...

Objects with broad boundaries are spatial objects, whose crisp boundaries are replaced by an area expressing the boundary’s uncertainty. There are two main interpretations for broad boundaries: (1) for positional uncertainty, the broad boundary represents the set of all possible positions among which the unknown boundary position is hidden; (2) for “fuzzy” boundaries, that is, boundaries that a...

Molting and metamorphosis in insects are under the control of two hormones, the steroid ecdysone and the sesquiterpenoid juvenile hormone (JH) (Riddiford, 1994) [We use the term ‘ecdysone’ as a generic term to refer to the natural ecdysteroids that cause molting and metamorphosis, primarily α-ecdysone and its metabolite 20-hydroxyecdysone (Riddiford et al., 2001).] Ecdysone induces and coordina...

Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promi...

Leiomyomas of an extrauterine nature are rare and often present a more challenging diagnosis process for the clinician. Our patient presented with lower abdominal pain associated with menorrhagia over a period of 6 months. Laparoscopic surgery revealed a right-sided broad ligament myoma consisting of multiple soft and diffused fibroids, of more than 400 in total. The myomas were enucleated and ...

Most businesses of today are increasingly becoming dependent on computer systems in their daily operation. Businesses need to respond quickly and accurately to be able to compete in their rapidly changing envi ronments. It is important that organizations and businesses become aware of the gain that could be realized by applying Integrated Computer Aided Software Engineering to their systems des...