OBJECTIVE To examine the effect of recurrent laryngeal nerve section on myonuclear addition and myofiber remodeling in adult rabbit laryngeal muscles. STUDY DESIGN AND SETTING Unilateral section of the recurrent laryngeal nerve was performed on adult rabbits. Rabbits were labeled with bromodeoxyuridine, euthanized, and the laryngeal muscles were examined for bromodeoxyuridine (brdU) and neona...

The effects of amethopterin, actinomycin D, and 5-bromodeoxyuridine on the differentiation of a cloned line of rat glioma is described. Amethopterin caused spongioblasts to develop rapidly into cells resembling astroblasts in culture. In time, these cells progressively differentiated into sheets of intertwining astrocytes that are morphologically like astroglia from normal rat brain grown under...

Introduction of the 5-halogenated uracil moiety into the deoxyribonucleic acid of several bacterial strains has been described by Weygand and Wacker (l), Zamenhof and Griboff (2), and Dunn and Smith (3). A corresponding introduction into the deoxyribonucleic acid of mammalian cells was recently reported by Eidinoff et al. (4, 5, 6) and by Prusoff (7) when 5-bromodeoxyuridine or 5-iododeoxyuridi...

Chromosome analysis, after bromodeoxyuridine incorporation and a sequential Leishman acridine orange staining method previously described, was used to assess the percentage of early or active fragile Xs compared with the overall total in informative cells in 13 heterozygous females. The percentage thus obtained was then used to calculate the percentage of early or active fragile X that would be...