نتایج جستجو برای: bruton
تعداد نتایج: 389 فیلتر نتایج به سال:
Cancer is one of the most common diseases in world. Th e transcription factor NF-κB plays a key role various physiological processes including immune response, cell proliferation, apoptosis and inflammation. Due to participation NF-kappa B signaling pathways carcinogenesis, angiogenesis, tumor resistance chemo- radiotherapy, considered be ideal target for pharmacological treatment cancer. paper...
Bruton tyrosine kinase (Btk), a non-receptor-associated tyrosine kinase of the Tec family, appears to participate in many myeloid cell functions. We show that macrophages from X-linked immunodeficient (XID) mice lacking functional Btk cannot generate efficient bursts of reactive oxygen intermediates (ROIs). The induction of apoptotic cell death by inflammatory stimuli is also enhanced in XID ma...
UNLABELLED Pancreas ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of all solid tumors, and thus new treatment strategies are urgently needed. Here, we report that targeting Bruton tyrosine kinase (BTK), a key B-cell and macrophage kinase, restores T cell-dependent antitumor immune responses, thereby inhibiting PDAC growth and improving responsiveness to standard-of-car...
The recognition of antigen by membrane immunoglobulin M (mIgM) results in a complex series of signaling events in the cytoplasm leading to gene activation. Bruton’s tyrosine kinase (BTK), a member of the Tec family of tyrosine kinases, is essential for the full repertoire of IgM signals to be transduced. We examined the ability of BTK to regulate the nuclear factor (NF)k B/Rel family of transcr...
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patie...
Mutations in the gene coding for Bruton ́s tyrosine kinase (Btk) lead to a lymphocyte differentiation block, which results in an extreme deficiency of B cells and plasma cells in the blood. These mutations are one cause of the hereditary immunodeficiency Xlinked agammaglobulinemia. Evolutionarily, Btk belongs to the Tec family of nonreceptor protein tyrosine kinases. Members of this family share...
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