Insulin causes a dramatic and rapid increase in phosphatidylinositol 3-kinase activity in the anti-phosphotyrosine immunoprecipitates of cells overexpressing the human insulin receptor. This enzyme may therefore be a mediator of insulin signal transduction [Endemann, Yonezawa & Roth (1990) J. Biol. Chem. 265, 396-400; Ruderman, Kapeller, White & Cantley (1990) Proc. Natl. Acad. Sci. U.S.A. 87, ...

Background and aims: Activation of Kupffer cells recruitment monocytes are key events in fibrogenesis. These release soluble mediators which induce the activation hepatic stellate (HSC), main fibrogenic cell type within liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes macrophages has been implicated pathogenesis NASH-related fibrosis. In this study, we explored if MerTK...

Tyrosine kinase inhibitors (TKIs) are the standard of care for patients with metastatic non-small cell lung cancers (NSCLC) harbouring epidermal growth factor receptor mutations (EGFRm). However, role TKIs is not established in management stage III EGFRm disease. We describe real-world practice testing and use NSCLC KINDLE study, a multicentre, multi-country observational non-interventional stu...

The present study is a case report of patient with diagnosis renal cell carcinoma poor prospects, in whom long-term tumor control at the level deep cytoreduction was achieved through aggressive multidisciplinary management using surgery, stereotactic radiotherapy, and sequential systemic therapy immunotherapy based on checkpoint inhibitor anti-PDL1 activity combined anti-angiogenic treatment, b...

Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as and/or Bcr-Abl TK inhibitors and performed lead optimization study to discover new generation derivative suitable for targeting. We synthesized 19 compounds,...

Adenosine and acetylcholine (ACh) trigger preconditioning by different signaling pathways. The involvement of phosphatidylinositol 3-kinase (PI3-kinase), a protein tyrosine kinase, and Src family tyrosine kinase in preconditioning was evaluated in isolated rabbit hearts. Either wortmannin (PI3-kinase blocker), genistein (tyrosine kinase blocker), lavendustin A (tyrosine kinase blocker), or 4-am...

Protein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia. Tyrosine kinases are enzymes expressed in multiple tissues and are involved in several signaling pathways influencing cellular growth. Below we describe a patient who developed an unusua...

The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety external signals. Small protein modules called Src homology 2 (SH2) SH3 domains mediate protein-protein interactions in signaling pathways that triggered tyrosine kinases. SH2 domain, module around 100 amino acids, is present kinase targets within the cell. recr...