Aim: To evaluate the long-term developmental trajectory of children with infantile spasms (IS) and identify clinical protective risk factors associated their cognitive outcome.Methods: We analyzed five-year follow-up results 41 (13 female) from previously published cohort (n = 68) recruited in a multicenter randomized controlled trial for 2-years, examining effect an adjunctive therapy (Flunari...

Background Advanced neuroimaging and computational methods offer opportunities for more accurate prognosis. We hypothesized that near-term regional white matter (WM) microstructure, assessed on diffusion tensor imaging (DTI), using exhaustive feature selection with cross-validation would predict neurodevelopment in preterm children. Methods Near-term MRI and DTI obtained at 36.6 ± 1.8 weeks p...

The aim of this study was to relate altered corpus callosum (CC) integrity in 106 very preterm (VPT) infants (<30 weeks' gestational age or <1250 g birth weight) at term equivalent to perinatal predictors and neurodevelopmental outcomes at two years. T1 and diffusion magnetic resonance images were obtained. The CC was traced, and divided into six sub-regions for cross-sectional area and shape a...

OBJECTIVE To study the factors affecting a neurodevelopmental status of children with congenital hypothyroidism, diagnosed on national screening program. METHODS The study was performed in the Pediatric Endocrinology Department of Dr. Behcet Uz Children's Hospital between May 2012 and May 2013. Children with congenital hypothyroidism, aged between 24 and 36 months, diagnosed by national scree...

Most of the developmental instruments that measure cognitive development in children rely heavily on fine motor skills, especially for young children whose language skills are not yet well developed. This is problematic when evaluating the cognitive development of young children with motor impairment. The purpose of this study is to assess the need for a Low Motor adapation of a standardized in...

BACKGROUND AND PURPOSE DEHSI on T2-weighted MR imaging in preterm infants at term-equivalent age has been regarded as an unfavorable marker for neurodevelopmental outcome. The aim of this study was to examine the relationship between the presence and extent of DEHSI and neurodevelopmental outcomes. MATERIALS AND METHODS We evaluated the MR images of 160 preterm infants at term-equivalent age....

OBJECTIVE To perform neurodevelopmental evaluation at 18 to 24 months corrected age in very low birth infants (VLBW) with transient hypothyroxinemia. DESIGN Cohort study. SETTING Maternity teaching hospital. PATIENTS Premature infants who were previously evaluated for thyroid hormone values in the first weeks of life were included. INTERVENTION Data of these infants who weighed <1500 g ...

Introduction: Each year, about 15 million babies are born preterm, and 1 die due to complications of preterm birth. Antenatal corticosteroid is one the most effective evidence-based interventions that can reduce mortality morbidity in newborns. Objective: The purpose this study was evaluate effect antenatal corticosteroids on respiratory morbidities neurodevelopmental outcomes among neonates. M...

Hyperphenylalaninemia is a hereditary metabolic disorder that causes elevated blood phenylalanine (Phe). Hyperphenylalaninemias are classified as Phenylketonuria PKU (Phe > 6 mg/dL) or mild hyperphenylalaninemia (mHPA) (Phe 2–6 mg/dL). This study examines the cognitive functioning of early diagnosed children with mHPA compared with early diagnosed and treated children with PKU.Psychomotor devel...