Habituation phenomena and decrements of neural responses in isolated nervous structures have been related to depression of synaptic potentials (Bruner & Kehoe, 1970; Kandel et al. 1970; Horn & Wright, 1970; Zucker, 1972). However, previous research (Stephens, 1973) has shown that repeated intracellular stimulation of neurones in the isolated abdominal ganglion of Aplysia caUfomica produces resp...

effects in normal human, Fanconi’s anaemia and xeroderma pigmentosum cells. Br J Cancer 67:1285, 1993 3. Hang B, Yeung AT, Lambert MW: A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A cells. Nuclic Acids Res 21:4187, 1993 4. Yamashita T, Kupfer G, Naf D, Suliman A, Joenje H, Asano S, D’Andrea AD:...

When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by counting the number of successive significant univariate tests and then contrasting this number to a well-chosen critical value. However, in the literature, this meth...

The straightforward preparation of new modular oxazoline-containing bifunctional catalysts is reported employing a microwave-assisted Buchwald-Hartwig aryl amination as the key step. Covalent attachment of 2-(o-aminophenyl)oxazolines and pyridine derivatives generated in good-to-high yields a series of ligands in two or three steps in which each part was altered independently to tune the activi...

effects in normal human, Fanconi’s anaemia and xeroderma pigmentosum cells. Br J Cancer 67:1285, 1993 3. Hang B, Yeung AT, Lambert MW: A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A cells. Nuclic Acids Res 21:4187, 1993 4. Yamashita T, Kupfer G, Naf D, Suliman A, Joenje H, Asano S, D’Andrea AD:...

The Buchwald–Hartwig amination of arylhalides with the Pd–Josiphos complex is a very useful process for generation primary amines using ammonia as reactant. Density-functional theory (DFT) calculations are carried out to examine reaction mechanism this process. Although general C–N cross-coupling known, there still some open questions regarding effect chelate phosphine ligand and role base in R...

Rapid development of the copper-catalyzed amination aryl halides in beginning 21st century, known as Renaissance Ullmann chemistry, laid foundations for use this method a powerful tool construction C(sp2)-N bond and became rival Buchwald–Hartwig reaction. Various applications approach are well-documented number comprehensive more specialized reviews, overview form personal account Cu-catalyzed ...

Halogenverbrückte Methylnaphthyl (MeNAP)-Palladiumdimere werden als vielseitige-Pd-Quellen vorgestellt, die sich ideal für Entwicklung katalytischer Methoden und präparativer organischer Synthesen eignen. Durch einfaches Mischen mit Phosphin- oder Carben-Liganden sie in situ definierte, monoligierte Komplexe umgewandelt. Ihre katalytische Aktivität wurde anspruchsvollen Buchwald-Hartwig-, Heck-...

Palladium-catalysed C(sp(2))-N cross-coupling (that is, Buchwald-Hartwig amination) is employed widely in synthetic chemistry, including in the pharmaceutical industry, for the synthesis of (hetero)aniline derivatives. However, the cost and relative scarcity of palladium provides motivation for the development of alternative, more Earth-abundant catalysts for such transformations. Here we discl...

Schroeder-Kurth TM, Auerbach AD, Obe G (1989) Fanconi Anemia. Clinical, Cytogenetic and Experimental Aspects. Berlin, Germany, Springer Verlag Alter BP (1994) Clinical features of Fanconi anaemia. In: Young NS, Alter BP (eds) Aplastic Anaemia: Acquired and Inherited. W.B. Saunders, Philadelphia, pp 275-308 Auerbach AD, Buchwald M, Joenje H (2003) Fanconi anaemia. In: Vogelstein B, Kinzler KW (e...