The purpose of this study was to identify ways in which social support is related to the caregiving stress and well-being experienced by adult daughter caregivers. The study focused on a specific source of support, caregivers' husbands, and included reports from 126 caregivers and their husbands. Main and buffering effects of four types of support (emotional and instrumental support provided to...

Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back polarity remains consistent despite changes in front strength. How is this bufferi...

Both proteins and RNAs can misfold into non-functional conformations. Protein chaperones promote native folding of nascent polypeptides and refolding of misfolded species, thereby buffering mutations that compromise protein structure and function. Here, we show that RNA chaperones can also act as mutation buffers that enhance organismal fitness. Using competition assays, we demonstrate that ove...

Interactive audio–video applications over IP networks have subjective tradeoffs between fidelity and latency owing to packet buffering at the receiver. Increasing the buffering time improves the fidelity, whereas it degrades the latency. This paper makes the subjective tradeoff between fidelity and latency clear in a quantitative way. In addition, we examine the effect of tasks on the subjectiv...