In subjects with chronic obstructive pulmonary disease (COPD) computed tomographic (CT) lung density correlates with direct pathological measurements of the size of the distal airspaces, as well as with measurements of airflow limitation and impairment of the diffusing capacity. Thus, CT lung density can be used to quantify emphysema in life. We wanted to assess the use of CT scanning to detect...

Bullous disorders of newborn are a rare entity. Genetically inherited bullous disorders, especially the dystrophic and junctional types have a fatal course (1). Breach of the epidermis in the newborn predisposes them to sepsis.

Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination systemic and topical corticosteroids as well other immunomodulatory drugs. Dupilumab fully human monoclonal antibody acts antagonist against IL4Ra traditionally used the treatment atopic dermatitis. We present 80-year-old man moderate to severe bullous succe...

The ABCA12 gene encodes an ATP-binding cassette transporter vital to skin barrier function. In keratinocytes, transports ceramides into the lumen of lamellar bodies as part widely conserved water system. Alterations in are associated with autosomal recessive congenital ichthyoses: harlequin ichthyosis, non-bullous ichthyosiform erythroderma, and ichthyosis. We report a 4-month-old female who pr...

Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or generalized bullous lesions. In up to 20% of affected patients, bullae may be completely absent, and only excoriations, prurigo-like lesions, eczematous lesions, urticated lesions and/or infiltrated ...

Fig 1. Papules with overlying hemorrhagic crusting located on the proximal arm (underlying bruising is caused by recent trauma to the arm and is not a result of the patient’s hemorrhagic bullous dermatosis). INTRODUCTION Hemorrhagic bullous dermatosis is a rare, generalized skin reaction with unknown pathogenesis, described in association with heparin therapy. Heparin is known to cause injectio...

In a comparative study the conventional haematoxylin and eosin staining method was employed concomitantly with the peroxidase-antiperoxidase method in cases of bullous skin diseases. This study includes 40 cases of bullous diseases diagnosed on clinical grounds and confirmed by routine histology using conventional haematoxylin and eosin staining. Skin sections were stained by immunoperoxidase m...

Purpose To report the association of rubeosis iridis with chronic bullous degenerative peripheral retinoschisis. Observations A 63-year-old female presented with acute hyphema and neovascularization of the iris in association with elevated intraocular pressure. Posterior segment examination including imaging revealed no vascular occlusion as a potential cause. However, large, peripheral bullo...

OBJECTIVES To evaluate the outcomes of amniotic membrane transplantation for symptomatic relief in patients with bullous keratopathy. MATERIAL AND METHOD This retrospective study included 17 eyes (17 patients) with bullous keratopathy presenting with intractable pain or discomfort. The patients were enrolled from January 2000 to December 2004. Amniotic membrane transplantation was performed. ...

are the frequently reported side effects, adverse cutaneous reactions are extremely rare. There are a few reports of acute generalized exanthematous pustulosis caused by faropenem and meropenem. However, bullous skin eruptions have not been reported, yet the various types of bullous drug reactions are bullous fixed drug reactions (FDRs), Stevens–Johnson syndrome and toxic epidermal necrolysis, ...