BACKGROUND Local anesthetics are an important component of perioperative pain management, but the duration of action of available products is limited. We hypothesized that a single local infiltration of a novel bupivacaine liposome injectable suspension (AT-003) would provide clinically effective analgesia over a 72-h period. In a masked, randomized, placebo-controlled, multi-center pilot field...

Background: The study aims to evaluate whether instillation of levo-bupivacaine intraperitoneally decreases post-operative pain after laparoscopic gynaecological surgeries, using VAS Scale. Methods: Randomized placebo controlled double blinded conducted at tertiary care hospital in New Delhi. 90 ASA I & II women scheduled undergo elective surgeries. 20 ml 0.5% diluted with 40ml normal salin...

In a prospective randomized double blind clinical study, 120 patients of either sex in the age group of 25-65 years with ASA I and II, who were scheduled to undergo elective laparoscopic cholecystectomy were allocated to two groups of 60 patients each with regard to postoperative analgesia. In Group-I (n=60) the patients received Bupivacaine (0.5%) 20ml, instilled in gallbladder bed and the und...

Aims of Study In the case of tension-free vaginal tape (TVT) surgery, muscle strength is required for obtaining an adequate increase in abdominal pressure when conducting a stress test by coughing during the procedure. Consequently, although the procedure is frequently performed under local infiltration anesthesia, this requires the use of a large amount of local anesthetic. We employ the use o...

Axillary brachial plexus block is an effective method of anaesthesia for the surgeries performed on the hand, forearm and distal third of the arm. However it has the risk of serious complications such as cardiovascular and central nervous system toxicity. Levobupivacaine is a long acting amide local anaesthetic used for epidural, caudal, spinal, infiltration and peripheral nerve blocks. Levobup...

We have measured the effect of infiltration of the deep and superficial layers of the abdominal wound on morphine consumption and pain for 48 h after operation, in 40 patients undergoing total abdominal hysterectomy, in a double-blind randomized study. Patients received wound infiltration with 0.9% normal saline 40 ml or 40 ml of 0.25% bupivacaine with epinephrine 1:200,000. There were no signi...