OBJECTIVE To review the literature covering the epidemiology, clinical characteristics, longitudinal course, prognosis and clues for the assessment of the Pediatrics Bipolar Disorder (PBD). METHOD A computerized search in PubMed, looking for published articles since 1980. RESULTS During the last years, the PBD diagnosis has proliferated largely, with some studies reporting incidences betwee...

BACKGROUND Pediatric bipolar disorder (PBD) has attracted increasing attentions due to its high prevalence and great influence on social functions of children and adolescents. However, the pathophysiology underlying PBD remains unclear. In the present study, the resting-state functional magnetic resonance imaging (fMRI) was used to detect abnormalities of baseline brain functions in depressed P...

The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial ligand alternative through computational enrichment (REPLACE) strategy to develop inhibitors of protein-protein interactions has identified alternatives for the N-terminal tripeptide of a Cdc25C substrate. In addition, a peptide structure-activity relationship describ...

OBJECTIVE This study investigated whether the resilience of males with probable bipolar depression (PBD) can be strengthened and compared it to that of males with probable unipolar depression (PUD). METHODS Prospective data for 198 participants (PBD: 66, PUD: 66, normal control: 66) were analyzed. The participants' resilience, bipolarity and severity of depressive symptoms were evaluated at b...

It has been shown that for k = 8 or 9, there exists a BIBD(v, k, 1) for all positive integers v == 1 or k (mod k(k-1)), with some possible exceptions. We show that such designs exist for 49 of these exceptional values. A balanced incomplete block design (BIBD) with parameters (v, k, 1) is a pair (X, A) where X is a v-set and A is a family of k-subsets (where 2 < k < v) called blocks, such that ...

Polo-like kinases (Plks) play multiple roles in mitosis and cytokinesis in eukaryotes and are characterized by the C-terminal Polo-box domain (PBD), which is implicated in binding to Plk substrates, targeting Plk and regulating Plk activity. The Plk homolog in Trypanosoma brucei (TbPLK) possesses a similar architecture, but it lacks the crucial residues involved in substrate binding and regulat...

Today, simple analogue assistive technologies are transformed into complex and sophisticated sensor networks. This raises many new privacy issues that need to be considered. In this paper, we investigate how this new generation of assistive technology incorporates Privacy by Design (PbD) principles. The research is conducted as a case study where we use PbD principles as an analytical lens to i...

SecA, the preprotein translocase ATPase, has a helicase DEAD motor. To catalyze protein translocation, SecA possesses two additional flexible domains absent from other helicases. Here we demonstrate that one of these "specificity domains" is a preprotein binding domain (PBD). PBD is essential for viability and protein translocation. PBD mutations do not abrogate the basal enzymatic properties o...

In the present study, the oleaginous fungus Mortierella alpina CBS 754.68 was screened for arachidonic acidproduction using inexpensive agricultural by-products as substrate. Four oilcakes were analysed to choose the best substrate among them. Sunflower oilcake was the most effective substrate for ARA production followed by soybean, colza and olive oilcakes. In the next step, seven variables in...

Plackett-Burman design and Box-Behnken response surface methodology (RSM) was employed to optimize the medium components for the chitin deacetylase (CDA) activity from Bacillus amyloliquefaciens Z7. Plackett-Burman design was applied to determine the specific medium components affecting CDA activity and found that starch, chitin and MgSO4 were critical in augmenting CDA activity. These signific...