cardiovascular diseases with an incidence of approximately 50% are the main causes of death in most advanced countries and an increasing trend in the developing world as well. the world health organization estimates that 12 million people per year worldwide die from cardiovascular diseases. cardiovascular diseases are becoming an increasing problem worldwide and hypercholesterolemia has been co...

Rat liver ribosomes in uifro incorporated labeled amino acids into proteins which showed the immunological behavior of the plasma lipoproteins. The presence of carrier lipoprotein or carrier lipid was required for the isolation and ultracentrifugal purification of immunologically reactive, labeled low and high density lipoproteins. The identity of the lipoproteins was further characterized by s...

The incorporation of labeled acetate into lipids was studied in rat hepatocytes isolated after treatment of liver with collagenase and hyaluronidase. About 60% of the lipid radioactivity was in free cholesterol and 13% was in triglycerides. Acetate incorporation was markedly inhibited when human serum lipoproteins were present in the incubation medium. Very low, high, and low density lipoprotei...

conclusions there was no difference between the effects of 2 g of epa or dha supplementation for 12 weeks on the levels of total cholesterol, ldl-c, hdl-c, tc/hdl-c, tg/hdl-c, and ldl-c/hdl-c; however, it had a desirable effect on the level of tg in a way that the effect of dha was clearer. results from 105 included patients, 97 (31 in epa, 33 in dha, and 33 in control groups) completed the stu...

Structural lipids, primarily phospholipids and sterols, as well as energy-storage lipids such as triacylglycerols are insoluble in water. In the aqueous fluids of animals, they are carried as lipoproteins, complexes of lipids bound to polypeptides. These watersoluble lipoproteins can be separated into different classes, depending upon their hydrated densities. These classes include very low den...

The demonstration of a role for serum lipoproteins in lipid transport in health and disease has stimulated interest in the biological activity of the lipid and protein moieties of these substances. For these investigations the development of improved methods for separating the lipids from whole serum or from the serum lipoproteins themselves is important but fully acceptable methods are not yet...

The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, the underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate systemic lipid metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential lipid carriers that are so far known to be generated only in the fat body. In ...

To investigate the regulation of lipid uptake into the eel oocyte in more detail, effects of 11-ketotestosterone (11-KT) and lipid transporters (lipoproteins) were determined in vitro. Ovarian explants from previtellogenic Japanese eels (Anguilla japonica) were incubated for 28 days with 11-KT and/or with very low density lipoproteins (Vldl), low density lipoproteins (Ldl), or high density lipo...

Triglyceride-rich lipoproteins may be responsible for the lipid accumulation in macrophages that can occur in hypertriglyceridemia. Chylomicrons and very low density lipoproteins (VLDL, total and with flotation constant [S(f)] 100-400) from fasting hypertriglyceridemic subjects induced a massive accumulation of oil red O-positive inclusions in unstimulated peritoneal macrophages. Cell viability...