Previous research has shown that the adoption of quality management system and the implementation of knowledge management have effects on organizational performance. Yet, little attention has been paid to moderating conditions on the relationship among these variables. The main purpose of this research is to empirically examine the moderating role of adopting quality management system in the ef...

Business failure belongs to the most investigated topics in the business literature (Huang et al. (2008)). A plethora of works have addressed the problem using conventional statistical or machine learning techniques that are known to suffer from distributional assumptions, representational bias, statistical inconsistencies or over-fitting in generalization, and therefore bring results that have...

Dnmt2 enzymes are conserved in eukaryotes, where they methylate C38 of tRNA-Asp with high activity. Here, the activity of one of the very few prokaryotic Dnmt2 homologs from Geobacter species (GsDnmt2) was investigated. GsDnmt2 was observed to methylate tRNA-Asp from flies and mice. Unexpectedly, it had only a weak activity toward its matching Geobacter tRNA-Asp, but methylated Geobacter tRNA-G...

Although the DNA methyltransferase 2 family is highly conserved during evolution and recent reports suggested a dual specificity with stronger activity on transfer RNA (tRNA) than DNA substrates, the biological function is still obscure. We show that the Dictyostelium discoideum Dnmt2-homologue DnmA is an active tRNA methyltransferase that modifies C38 in tRNA(Asp(GUC)) in vitro and in vivo. By...

We provide an econometric analysis for the factor models when the latent factors can be explained partially by several observed explanatory proxies. In financial factor models for instance, the unknown factors can be reasonably well predicted by a few observable proxies, such as the Fama-French factors. In diffusion index forecasts, identified factors are strongly related to several directly me...

The diacylglycerol-carrying lipoprotein (DGLP) was purified from hemolymph of the locust, Locusta migratoria, by a rapid method which included a specific precipitation at low ionic concentration and DEAE-cellulose column chromatography. The final preparation was highly homogeneous as judged by gel electrophoresis, electron microscopy, and immunodiffusion. The locust DGLP molecule was almost sph...

Inositol phospholipids are critical regulators of membrane biology throughout eukaryotes. The general principle by which they perform these roles is conserved across species and involves binding of differentially phosphorylated inositol head groups to specific protein domains. This interaction serves to both recruit and regulate the activity of several different classes of protein which act on ...

p63 is a crucial regulator of epidermal development, but its transcriptional control has remained elusive. Here, we report the identification of a long-range enhancer (p63LRE) that is composed of two evolutionary conserved modules (C38 and C40), acting in concert to control tissue- and layer-specific expression of the p63 gene. Both modules are in an open and active chromatin state in human and...

In the paper, we suggest three tests on the validity of a factor model which can be applied for both, small-dimensional and large-dimensional data. The exact and asymptotic distributions of the resulting test statistics are derived under classical and highdimensional asymptotic regimes. It is shown that the critical values of the proposed tests can be calibrated empirically by generating a samp...

OBJECTIVE Pay-for-performance programmes have been widely implemented in primary care, but few studies have investigated their potential adverse effects on the intrinsic motivation of general practitioners (GPs) even though intrinsic motivation may be a key determinant of quality in health care. Our aim was to compare methods for developing a composite score of GPs' intrinsic motivation and to ...