نتایج جستجو برای: cad pathogenesis

تعداد نتایج: 143211  

2016
Abdulaziz A. Al-Jafari Mohamed S. Daoud Farid S. Ataya

Genetic factors play a pivotal role in the development and pathogenesis of coronary artery disease (CAD). The angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism is one of the various genetic factors associated with CAD. In this study, we investigated the association between the ACE gene I/D polymorphism and CAD in the Saudi population. A total of 210 CAD patients w...

2011
M Ebrahimi S M R Kazemi-Bajestani M Ghayour-Mobarhan G A A Ferns

BACKGROUND Coronary artery disease (CAD) is a leading cause of mortality, morbidity, and disability in the world. The high prevalence and morbidity associated with CAD in Iran is one of the most pressing health problems. METHODS We have reviewed the status of CAD and prevalence of its traditional and novel risk factors based on the published papers in recent years that may have an impact on t...

Journal: :Clinical chemistry 2012
Robert Roberts Alexandre F R Stewart

BACKGROUND It has long been recognized that 50% of the susceptibility for coronary artery disease (CAD) is due to predisposing genetic factors. Comprehensive prevention is likely to require knowledge of these genetic factors. CONTENT Using a genomewide association study (GWAS), the Ottawa Heart Genomic Study and the deCODE group simultaneously identified the first genetic risk variant, at chr...

2013
Fulvia Gloria-Bottini Krzysztof Safranow Maria Banci Agnieszka Binczak-Kuleta Patrizia Saccucci Andrzej Ciechanowicz Andrea Magrini Zdzislawa Kornacewicz-Jach Egidio Bottini Dariusz Chlubek

An association between ADA1 and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without C...

2010
Sunita Dodani

South Asian immigrants (SAIs) have a higher prevalence of cardiovascular (CV) morbidity and mortality compared with other populations. The major challenge associated with primary prevention of cardiovascular to coronary artery diseases (CAD) in SAIs involves early and accurate detection of CAD in asymptomatic individuals at high cardiovascular risk. Inflammatory processes are now recognized to ...

Journal: :The Medical journal of Malaysia 2015
N H Yong Sheng Tan A Sachithanandan

The incidence of premature multi-vessel coronary artery disease (CAD) is on the rise in Malaysia. The pathogenesis of coronary atherosclerosis is multi-factorial with dyslipidaemia being one such risk factor. Elevated total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) levels are primarily responsible. We analysed the fasting pre-operative lipid profiles o...

Journal: :Circulation 2002
Olaimatu S Mahdi Benjamin D Horne Kelly Mullen Joseph B Muhlestein Gerald I Byrne

BACKGROUND Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous studies, cross-reactive heat shock protein (Hsp) antibody responses have been causally linked to CAD, and the severity of chlamydial disease pathogenesis correlates with Hsp serology. Our aim was to determine if chlamydial Hsp (cHsp) antibody responses ar...

2016
Qi Qian Zhihui Ma Lijuan Chen Chengchun Tang Genshan Ma Zhong Chen

Objective: PLCL2 is expressed in lymphocytes and platelets, and these cells play a pivotal role in the pathogenesis of atherosclerosis. AP3D1-DOT1L-SF3A2, expressed in lymphocytes and endothelial cells, also has an important role in the progression of atherosclerosis. Recently, a genome-wide association study identified PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infar...

2017
Kae-Woei Liang Wayne H.-H. Sheu Wen-Jane Lee Wen-Lieng Lee Hung-Chih Pan I.-Te Lee Jun-Sing Wang

BACKGROUND Cardiac syndrome X (CSX) is characterized by angina pectoris but with patent coronary arteries. Our previous study demonstrated that subjects with CSX had a higher fasting insulin-resistance (IR) than the controls. However, few studies have investigated the degree of IR, including oral glucose tolerance test (OGTT)-derived indices and profiles of metabolic abnormalities between CSX a...

2016
Liting Zhou Dongchun Zheng Shuyue Wang Jian Zhu Yiyang Jia Di Sun Jin Xu Qi Wang Huaiji Chen Feng Xu Bo Li Lin Ye

PURPOSE Toll-like receptor 4 (TLR4) is known to be involved in innate immunity and inflammatory responses that play important roles in the pathogenesis of coronary artery disease (CAD). But the relationship between TLR4 gene and CAD has yet to be investigated. The present study aimed to evaluate the association of TLR4 gene polymorphisms with CAD susceptibility in a Chinese Han population. ME...

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