This consensus reviewed the main current issues of clinical application and integration into everyday practice a new targeted preventive therapy for migraine using monoclonal antibodies (mAbs) to calcitonin gene related peptide (CGRP) ligand or receptor. These recommendations are based on scientific studies an analysis results several years use. The purpose is assist practitioners in prescribin...

BACKGROUND AND PURPOSE The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1-7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3-6 and 8-9, excluding Cys-2 and...