Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension. We and others have recently shown that cyclic stretch and shear stress activate TRPV4-mediated calcium influx in endothelial cells (EC). In addition to the mechanical forces, acetylcholine (ACh) was shown to activate TRP...

Calcium is a ubiquitous second messenger that plays a critical role in both excitable and non-excitable cells. Calcium mobilisation in identified cell types within an intact renal epithelium, the Drosophila melanogaster Malpighian tubule, was studied by GAL4-directed expression of an aequorin transgene. CAP2b, a cardioactive neuropeptide that stimulates fluid secretion by a mechanism involving ...

Chicken eggs are the most important cooking ingredient with rich protein and calcium. It can be consumed by all humans eggshells disposed as a waste material to environment. These materials directly in environment without any pre-treatment which creates environmental pollution its microbial action. Nowadays, researchers converting these into valuable biomaterials. More than 2.2 million people w...

Emerging evidence suggests that plasma membrane calcium ATPases (PMCAs) play a key role as regulators of calcium-triggered signal transduction pathways via interaction with partner proteins. PMCAs regulate these pathways by targeting specific proteins to cellular sub-domains where the levels of intracellular free calcium are kept low by the calcium ejection properties of PMCAs. According to thi...

PURPOSE The aim of this study was to elucidate the sequence of very early bystander signalling events and to determine the role of the different signalling molecules in both the production of the bystander signal and the response to this signal. MATERIALS AND METHODS Human keratinocytes (HaCaT cell line) were irradiated (0.005, 0.05 and 0.5 Gy) using a cobalt 60 teletherapy unit, the medium w...

UNLABELLED Calcium oxide, available for decades as a root canal filling material, has been little used in recent years due to its lack of radio-opacity, and an expectation that it would lead to an excess of root fractures. In this study, four general dentists submitted 79 cases of endodontically treated teeth whose roots were filled with either Biocalex 6/9, or Endocal-10, and rendered adequate...