Domen developed a sealed water calorimeter at NIST to measure absorbed dose to water from ionizing radiation. This calorimeter exhibited anomalous behavior using water saturated with gas mixtures of H2 and O2. Using computer simulations of the radiolysis of water, we show that the observed behavior can be explained if, in the gas mixtures, the amount-of-substance of H2 and of O2 differed signif...

We outline a practical scheme for measuring the thermodynamic properties of a Bose–Einstein condensate as a function of internal energy. We propose using Bragg scattering and controlled trap manipulations to impart a precise amount of energy to a near-zero temperature condensate. After thermalization the temperature can be measured using standard techniques to determine the state equation T (U,...

Isothermal titration calorimetry (ITC) is a fast and robust method to study the physical basis of molecular interactions. A single well-designed experiment can provide complete thermodynamic characterization of a binding reaction, including K(a), DeltaG, DeltaH, DeltaS and reaction stoichiometry (n). Repeating the experiment at different temperatures allows determination of the heat capacity ch...

effects of ?-cyclodextrin, ?cd, on refolding of lysozyme was investigated at ph 12 employing isothermal titration calorimetry (itc) at 300k in 30mm tris buffer solution. ?cd was employed as an anti-aggregation agent and the heats obtained for lysozyme+?cd interactions are reported and analyzed in terms of the extended solvation model. it was indicated that there are two sets of identical and no...

SYMPOSIUM PROCEEDINGS I956 The bottleneck in the application of indirect calorimetry is still the need for laborious and skilful gas analysis. I t is this bottleneck that is now under attack in this laboratory. If the attack is successful, the results will be, first a robust oxygen analyser for laboratory use, with a very short response time and small dead space, and later an adaptation of it s...

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BACKGROUND AND OBJECTIVES Energy expenditure in severe sepsis/septic shock patients was measured by indirect calorimetry and the correlation of energy expenditure between indirect calorimetry and predictive equations was determined. METHODS AND STUDY DESIGN This was a prospective, observational analytical study. Severe sepsis or septic shock patients were measured for energy expenditure over ...

One key factor in stabilization of protein drugs in liquid formulations is the choice of appropriate excipients at optimum concentrations that provide extended shelf life while also ensuring highest safety to the patient. Although general principles of stabilization have emerged from the literature over the past decade, the mechanisms by which excipients can improve the stability of a protein d...