A special form of prostate cancer is non-metastatic castration-resistant cancer. Patients with this have rising prostate-specific antigen and castrate testosterone levels, no radiological findings metastatic disease on computed tomography bone scan. The phase III trials demonstrated apalutamide, darolutamide or enzalutamide to be associated a significantly longer median metastasis-free survival...

BACKGROUND A reagentless sensor array for simultaneous multianalyte testing (SMAT) may enable accurate diagnosis and be applicable for point-of-care testing. We developed a disposable reagentless immunosensor array for simple immunoassay of panels of tumor markers. METHODS We carried out SMAT with a direct capture format, in which colloidal gold nanoparticles with bound horseradish peroxidase...

Abstract. Currently, there is no doubt about the feasibility of determining frequency HLA and analysis genetic associations, including those that determine state immunity, in patients with genitourinary disease.
 The study aimed to evaluate phenotypes most common diseases system identify risk antigens or protectors.
 Methods. distribution was studied 384 pyelonephritis glomerulonephri...

Merkel cell carcinoma (MCC) is a rare and aggressive cancer of the skin with ∼30% mortality. Around 80% MCC tumors originate from integration polyomavirus (MCPyV) DNA into host genome, leading to expression viral T-antigen oncoprotein ultimately, tumorigenesis. Though PD-1 pathway blockade has significantly improved outcomes for advanced MCC, many patients do not benefit or develop resistance t...