We hypothesized that lung inflammation and parenchymal apoptosis in ventilator-induced lung injury (VILI) are related to ANG II and assessed the ability of the angiotensin-converting enzyme inhibitor captopril to attenuate VILI in rats. Adult male Sprague-Dawley rats were randomized to receive two ventilation strategies for 2 h: 1) tidal volume of 40 ml/kg, respiratory rate of 25 breaths/min, a...

Introduction. As a result of the coronavirus infection (COVID-19) pandemic, almost 74.9 thousand people died pneumonia in Russia 2021. Community-acquired (CAP) is accompanied by systemic re­sponse body to inflammation lung tissue and disorder microhemocirculation. The method laser Doppler flowmetry (LDF) allows assessing general parameters microcirculatory bed determining state various factors ...

In 1970 , 1971 and 1973 in a single dairy farm a total of 20 6 German red pied heifers were subjected to synchronization treatment. Treatment schedules consisted of chlormadinone acetate (CAP) given orally daily for i8 days io mg/day). Half of the animals were used to measure the effect of additional hormones on conception rate. 3r heifers received 5 mg of estradiol benzoate, 35 animals, i,ooo ...

Literature about the value of diagnostic tests for hazelnut allergy in children is scarce. For peanut allergy cutoff levels of specific IgE with a 95% positive predictive value (PPV) were published. To evaluate current diagnostics for hazelnut allergy in children, data of 151 children, who underwent a double-blind placebo-controlled food challenge (DBPCFC) for hazelnut were analyzed. The PPV or...

Direct Numerical Simulations are performed to investigate the gas-liquid mass transfer around a rising spherical bubble contaminated by insoluble surfactants. The surfactant transport on surface and Marangoni effect taken into account when solving hydrodynamics, resulting in stagnant-cap condition. A parametric study is carried out varying Reynolds, Schmidt numbers. thorough analysis of impact ...

BACKGROUND A number of minimally invasive technologies exist for the treatment of prostate cancer (CaP), each with their associated morbidities. We sought to test the efficacy of low dose alternating electric current (LDAEC) to inhibit CaP growth in a preclinical setting and determine its effect on normal tissue. METHODS In the first study, two power settings, 15 or 25 mA of current, and two ...

We evaluated HER-2/neu status in 100 consecutive ductal breast carcinomas by using the Food and Drug Administration (FDA) and American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) scoring systems. With the FDA system, scores were 3+ in 23.0%, 2+ in 25.0%, and 0 or 1+ in 52.0% of cases. With the ASCO/CAP system, scores were 3+ in 16.0%, 2+ in 34.0%, and 0 or 1+ in 50....

Background Community-acquired pneumonia (CAP) represents one of the main causes mortality and morbidity among under-five children worldwide. More than 75% these fatalities are caused by severe pneumonia. Objectives to identify potential risk factors associated with CAP hospitalized CAP. Patients Methods This prospective observational study was conducted on children, aged 1 59 months, who were a...

BACKGROUND AND PURPOSE Rupture of the plaque fibrous cap and subsequent thrombosis are the major causes of stroke. This study evaluated morphologic features of plaque rupture in the carotid artery by using optical coherence tomography in vivo. MATERIALS AND METHODS Thirty-six carotid plaques with high-grade stenosis were prospectively imaged by optical coherence tomography. "Plaque rupture" w...

BACKGROUND Rapid molecular diagnostics for detecting multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) primarily identify mutations in Mycobacterium tuberculosis (Mtb) genes associated with drug resistance. Their accuracy, however, is dependent largely on the strength of the association between a specific mutation and the phenotypic resistance of the isolate with that m...