The secretory pathway in plants mediates the transport of cargo molecules from their site of synthesis to other compartments within the pathway as well as to the cell wall. At the centre of this system is the Golgi apparatus, a transport hub that is responsible for receiving, modifying and sorting proteins for transport to their destinations. Several recent publications have investigated the ro...

The present paper deals with a variant of hub location problems (HLP): the uncapacitated single allocation p-Hub median problem (USApHMP). This consists to jointly locate facilities and allocate demand nodes these selected facilities. objective function is minimize routing demands between any origin destination pair nodes. known be NP-hard. Based on artificial immune systems (AIS) framework, th...

In many real-world transportation systems, passengers are often required to make a number of interchanges between different modes of transport. As cities continue to grow, a greater number of these connections tend to occur within centrally located Transport Hubs. In order to encourage the uptake of public transport in major cities, it is important for passengers to be able to connect between t...

M Calzolari ([email protected])1, P Angelini2, A C Finarelli2, R Cagarelli2, R Bellini3, A Albieri3, P Bonilauri1, F Cavrini4, M Tamba1, M Dottori1, P Gaibani4, S Natalini5, G Maioli1, M Pinna1, A Mattivi2, V Sambri6, A Pierro4, M P Landini4, G Rossini4, G Squintani5, S Cinotti1, S Varani4, C Vocale4, E Bedeschi2 1. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Ro...

The hub location problem deals with finding the location of hub facilities and allocating the demand nodes to these hub facilities so as to effectively route the demand between any origin–destination pair. In the extensive literature on this challenging network design problem, it has widely been assumed that the subgraph induced by the hub nodes is complete. Relaxation of this basic assumption ...

Although papillary renal cell carcinoma (PRCC) accounts for 10%-15% of renal cell carcinoma (RCC), no predictive molecular biomarker is currently applicable to guiding disease stage of PRCC patients. The mRNASeq data of PRCC and adjacent normal tissue in The Cancer Genome Atlas was analyzed to identify 1148 differentially expressed genes, on which weighted gene co-expression network analysis wa...

OBJECTIVE We analysed the integrated planning model adopted by the Italian region Emilia Romagna in year 2000 to cover the entire range of treatment of cardiovascular disease. This model, called "hub and spoke", provides for the transfer of patient care and treatment from peripheral units (the spokes) to central units (the hubs) once a certain complexity threshold has been reached. METHODS We...

Capacitated p-median problem (CPMP) is a well-known facility-location problem, in which p capacitated facility points are selected to satisfy n demand points in such a way that the total assigned demand to each facility does not exceed its capacity. Minimizing the total sum of distances between each demand point and its nearest facility point is the objective of the problem. Developing an effic...

Considering the problems of heterogeneous informa-tion system integration, service-oriented component of HUB-SOA model is proposed based on investigating E-HUB integration model and SOA integrated structure. Further, the key technical of the basic working principle, interface model, web service, system component and schema mapping are researched. What’s more, WEB service and its description of ...