Introduction: Over the past few decades, antimicrobial resistance (AMR) has skyrocketed globally among bacteria within Family Enterobacteriaceae (i.e. Enterobacter spp, Klebsiella Escherichia coli, Proteus Serratia marcescens, Citrobacter and others). are intestinal flora important pathogens in nosocomial community settings. spread easily between humans may acquire AMR via plasmids or other mob...

Background: In African countries, where the burden of neonatal sepsis is highest, spread Carbapenemases Producing Enterobacteriaceae (CPE) in community, potentially contributing to mortality, a public health concern. The transmission routes are not well defined, particularly possible key role played by pregnant women. aim this study was understand acquisition CPE Yaounde, Cameroon. Methods: A t...

BACKGROUND Acinetobacter baumannii is a significant hospital pathogen, possessing a considerable degree of antimicrobial resistance. A. baumannii resistance to carbapenems and aminoglycosides is mostly conferred by class D OXA carbapenemases and aminoglycoside-modifying enzymes, respectively. The aim of this study was to determine the prevalence of selected genes encoding OXA carbapenemases and...

BACKGROUND NXL104 potentiates ceftazidime and ceftaroline against Enterobacteriaceae with extended-spectrum, AmpC, KPC and OXA β-lactamases. We examined whether similar potentiation was obtained against non-fermenters, which are less permeable than Enterobacteriaceae and have more potent efflux. METHODS MICs of ceftazidime+NXL104 (with NXL104 at 4 mg/L) and comparators were determined by CLSI...

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) co-carrying multiple carbapenemases is complicating clinical treatment. This study aimed to investigate the global dissemination trends CRKP strains that co-carry carbapenemases. isolate KP424 blaNDM-1 and blaKPC-2, recovered from a stool specimen, was identified by NG-Test Carba 5 test, genome sequence further determined using ...

Background: Resistance to carbapenems due carbapenemases has been increasingly noticed worldwide. Detection of among Gram‑negative bacteria (GNB) is important for
 both clinicians and infection control practitioners. Both phenotypic molecular methods can be used for detection Carbapenemases production. Molecular although the gold standard are not routinely as they might immediately availab...

Abstract Introduction: This study provides data on carbapenemases identified in carbapenem-resistant Klebsiella pneumoniae (CR-KP) isolated from blood-cultures by the multiplex molecular method. Material and method : Between October 2016 September 2017, 47 non-duplicate (KP) were blood cultures, hospitalized patients Regional Institute of Gastroenterology Hepathology, Cluj-Napoca, Romania. Iden...

The emergence of the Klebsiella pneumoniae carbapenemases in K. pneumoniae and other Gram-negative bacteria, usually on a background of multidrug resistance, has led to difficult therapeutic choices. Among available antibiotics, tigecycline and the polymyxins are the most frequently active against these organisms in vitro. Optimal therapy of infections due to these bacteria may involve maximiza...