one of the major classes of ionotropic glutamate receptors is the class of n-methyl-d-aspartate receptors (nmdars). receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to excitotoxicity and neuronal death. in...

Most human selenium containing proteins contain selenium in the form of the amino acid selenocysteine, which is encoded in the corresponding mRNA as a UGA codon. Only a few non-selenocysteine containing selenoproteins are present and the nature of the association with selenium is not well understood. This review focuses on two selenocysteine-containing proteins that are members of the glutathio...

1 2 3 4 5 6 7 8 9 10 11 12 The present study is aimed to investigate the effect of a commercial plant extract (RP) on the stability of fish during frozen storage. For it, horse mackerel (Trachurus trachurus) fillets were soaked in water (Water Control) and two RP concentrations (0.333%, RP-1; 1.333%, RP-2) and compared to untreated fillets (Blank Control). Fluorescence detection and thiobarbitu...

BACKGROUND Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase...

Background: Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidas...

wide range of products is available; from inorganic, sodium selenite or selenate coated or not, even nanoparticles to organic forms such as selenized yeasts, chelates of selenium methionine (SeMet), pure forms of SeMet or hydroxy-selenomethionine, and some complexes sources of Se based on mixing mineral Se with glycinates, proteinates, etc. It has been confirmed that, comparing with mineral sel...

The study was designed to assess the relationship between red cell glutathione peroxidase and serum selenium as well as lipids and lipoprotein in HIV positive blood donors. Thirty five subjects consisting of twenty HIV positive blood donors with a mean age of 34±2.18 years and fifteen HIV negative blood donors with a mean age of 43±2.18 years controls were selected for this study. Erythrocyte g...

Peroxiredoxin VI (PrxVI) is a bifunctional enzyme with non-selenium glutathione peroxidase and Ca2+-independent acidic phospholipase A2 activities. We demonstrate that transfection-mediated PrxVI overexpression protects immortalized human WI-38 and murine NIH3T3 fibroblasts against cytotoxic doses of tert-butylhydroperoxide and H2O2. Mutants for either glutathione peroxidase or phospholipase A2...