In the present study, cigarette smoke (CS) exposure significantly enhanced 3H-B(a)P-DNA adduct formation in both the pulmonary and hepatic tissues. Mice co-treated with CS and celecoxib (a specific COX-2 inhibitor) exhibited a significant decrease in hepatic carcinogen-DNA adduct formation in comparison to the smoke exposed group, however the lungs of the co-treated animals exhibited a signific...

The effects of sodium cyanate, ferf-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting 1 week following completion of carcinogen administra tions. Under these conditions, all three test compounds exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of th...

The incidence of chromosome aberrations in rat bone marrow, examined 6 hr after the administration of 7,12-dimethylbenz(a)anthracene, was significantly enhanced by induction of anemia 0-48 hr before the carcinogen treatment and was suppressed by induction of polycythemia. The suppressive influence of polycythemia was reversed by sheep erythropoietin injected shortly before or after the carcinog...