INTRODUCTION: In cardiac imaging, respiratory motion causes image artifacts and ghosting. Over the past two decades, several approaches have been proposed to minimize motion artifacts such as breath-holding, respiratory navigators or self-gating [1]. In high resolution imaging, respiratory navigators using a 2D selective RF excitation typically positioned on the right hemi-diaphragm, have been ...

BACKGROUND The aortic pulse-wave velocity (PWV) is an important indicator of cardiovascular risk. In recent studies MRI methods have been developed to measure this parameter noninvasively in mice. Present techniques require additional hardware for cardiac and respiratory gating. In this work a robust self-gated measurement of the local PWV in mice without the need of triggering probes is propos...

The effects of gating systems, number of runner, and their locations, in the Lost Foam Casting (LFC) of Aluminum alloy (A.413.0) were investigated. Six different gating systems, with one or two running systems were designed. X-ray radiography and the three axis-bending tests have been employed to evaluate the casting soundness and quality. The results revealed that gating systems have a major e...

HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K+ channel vital to normal repolarization of cardiac action potentials. Attenuation of repolarizing K+ current caused by mutations in HERG or channel block by common medications prolongs ventricular action potentials and increases the risk of arrhythmia and sudden death. The critical role of HERG in maintenance of normal cardia...

We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bilayers, and trypsin was applied to the luminal side of the bilayer. We found th...

Abstract Unmonitored cardiac images of a rat were acquired using standard gradient echo sequences to study the artefact ghosting mainly caused by heart and respiration motion. All imaging experiments performed transceiver circular-shaped coil preclinical magnetic resonance imager at 7 T. Heart showed along frequency encoding direction. However image quality was not drastically affected this typ...

Background Displacement Encoding with Stimulated Echoes (DENSE) directly measures tissue displacements and can be used to quantify cardiac mechanics. Multi-dimensional DENSE results in lengthy scans that require respiratory gating, acquiring data only while the diaphragm is within a prespecified “acceptance window.” Because it is not possible to perform respiratory gating during data acquisitio...

Voltage sensor domains (VSDs) are a feature of voltage gated ion channels (VGICs) and voltage sensitive proteins. They are composed of four transmembrane (TM) segments (S1-S4). Currents leaking through VSDs are called omega or gating pore currents. Gating pores are caused by mutations of the highly conserved positively charged amino acids in the S4 segment that disrupt interactions between the ...