OBJECTIVE Most neonatal encephalopathic disorders appear to be caused by perinatal events. Persistent myocardial ischemia leads to cellular necrosis and release of troponin from cardiac muscles. Fetal distress during labor may be detected by monitoring the fetal heart rate. However little is known about the relationship, if any, that exists between fetal heart rate abnormalities and the fetal c...

1. Karajalainen J, Heikkilä J. Acute pericarditis: myocardial enzyme release as evidence for myocarditis. Am Heart J 1986;111:546–552. 2. Perry SV. The regulation of contractile activity in muscle. Biochem Soc Trans 1979;7:593–617. 3. Adams JE, Bodor GS, Dávila-Román VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin I: a marker with high specificity for cardiac injury. Circulatio...

BACKGROUND A postoperative troponin leak that was previously considered clinically insignificant has been independently associated with 30-day mortality in unselected surgical patients ≥45 years of age following non-cardiac surgery. OBJECTIVES To determine whether routine troponin surveillance following non-cardiac surgery and initiation of aspirin and statin therapy in troponin-positive pati...

It is now well known that, as compared to all other cardiac markers the cardiac Troponin-I and CK-MB are found to be more reliable for the diagnosis of myocardial infarction (MI). The aim of our study was to assess the comparative role of CK-MB and Troponin-I in the diagnosis of non-ST elevation MI (NSTEMI) where there is minimal cardiac damage. Design: The study comprised of 50 patients presen...

As we move into the new Millennium, “the times they are a changin” regarding the diagnostic criteria used to rule in and rule out acute myocardial infarction (AMI) (1 ). The purpose of this editorial is to comment on the new cardiology guidelines for the redefinition of AMI and unstable angina, as well as to compare them with previously published laboratory medicine recommendations. Some of the...

Troponin T is a thin filament protein that is important in regulating striated muscle contraction. We have raised a monoclonal antibody against rabbit cardiac troponin T, monoclonal (mAb) 13-11, that recognizes its epitope in cardiac troponin T isoforms from fish, bird, and mammal but not from frog. The number of these isoforms expressed in cardiac muscle varies among species and during develop...

AIMS Elevation of troponin T in patients with unstable angina is predictive of adverse outcomes. Since no advanced therapeutic concept for such high-risk patients has been established, we investigated cardiac risk prior to, during, and after coronary revascularization in patients with unstable angina stratified according to the troponin T status. METHODS AND RESULTS Out of 351 patients with u...

BACKGROUND Immunoassays are prone to interference by various substances which may cause inaccurate results. This type of interference is difficult to detect analytically. OBJECTIVE A case of CARDIAC Troponin T Quantitative reader (Roche Diagnostics) assay failure was detected and investigated in order to ascertain the likely cause. METHOD Patient whole blood was mixed with cardiac troponin ...