An overview of the presentation, clinical and radiographic features, and management of the most common benign pediatric bone tumors will be presented below. Malignant bone tumors (Ewing sarcoma and osteosarcoma) are discussed separately. (See "Clinical presentation, staging, and prognostic factors of the Ewing sarcoma family of tumors" and "Osteosarcoma: Epidemiology, pathogenesis, clinical pre...

here, we describe young men with synovial sarcoma in the palatine tonsil, who presented with a 3-4 month history of progressive sore throat, tonsillar ulcerative mass and bleeding. clinical and radiological examinations revealed that the tumors arose from the palatine tonsil and extended to the parapharyngeal space. both tumors were too advanced to remove completely; therefore, they underwent s...

background ewing’s sarcoma family is a group of small round cells tumors. the aim of this study is to evaluate clinicopathologic characteristics and outcome of ewing’s sarcoma in children and adolescents in yazd, iran. materials and methods all patients under 19 years with documented pathology of ewing’s sarcoma family tumor who referred to shahid ramazanzadeh radiotherapy center between 2002 t...

BACKGROUND & OBJECTIVE Peripheral tumor growth pattern plays an important role in the local recurrence and metastases of soft tissue sarcoma. This study was to determine the peripheral growth pattern of soft tissue sarcoma by magnetic resonance imaging (MRI), explore its correlation to histological grade, and assess biological features of soft tissue sarcoma before operation. METHODS MRI was ...

Peripheral neuroepitbelioma (PN) is a rare highly malignant tumor, classified in the group of small round cell tumors. We report eight cases of PN, based on histologic appearance and immunohistochemical staining for neuron-specific enolase (NSE). Electron microscopy was also performed in three cases. The tumors exhibited rapid local growth, leading to limb amputation in five cases. Histolo...

The efficacy of current standard therapies for the treatment of sarcoma remains limited. With the aim of identifying target antigens relevant to the development of vaccine-based immunotherapy of sarcoma, we have addressed the relevance of tumor-specific antigens encoded by genes belonging to the SSX family as vaccine targets in sarcoma tumors. Expression of SSX-1 to -5 was analyzed in a collect...

High-grade endometrial stromal sarcoma is a rare uterine malignancy. The cells of these tumors resemble endometrial cells in the proliferation stage, with many small plexiform arterioles. Herein we present a patient with endometrial stromal sarcoma that metastasized to the brain, along with the CT and MRI findings and a discussion of the surgical and histopathological features of the metastatic...

primary cardiac tumors are quite rare, especially in the pediatric age group, and their atypical presentations often prevent a timely diagnosis. most primary cardiac tumors in the pediatric age group are benign. fibromas are generally reported as the second most common primary cardiac tumors in the pediatric age group. these neoplasms are often intramural and involve the left ventricular free w...

BACKGROUND Sarcomas are rare mesenchymally derived tumors for which there are limited treatment options. This paper discusses the current therapeutic potential of directed tyrosine kinase inhibitors (TKIs) in sarcoma. METHODS The authors review antibody-based strategies and small molecular inhibitors of TKIs, with specific emphasis placed on the potential use of these targeted agents as thera...

OBJECTIVE Controversy exists about the treatment outcomes of the Ewing sarcoma family of tumors among low-incidence populations. We evaluated whether Korean Ewing sarcoma family of tumors patients have poorer outcomes than Euro-American patients. METHODS We retrospectively analyzed the clinicopathologic characteristics and outcomes of patients with localized Ewing sarcoma family of tumors tre...