Chandra observations of the Cartwheel galaxy reveal a population of ultraluminous X–ray sources (ULXs) with lifetimes <∼ 10 7 yr associated with a spreading wave of star formation which began some 3 × 10 yr ago. A population of high–mass X–ray binaries provides a simple model: donor stars of initial masses M2 >∼ 15M⊙ transfer mass on their thermal timescales to black holes of masses M1 >∼ 10M⊙....

Basal body replication during estrogen-driven ciliogenesis in the rhesus monkey (Macaca mulatta) oviduct has been studied by stereomicroscopy, rotation photography, and serial section analysis. Two pathways for basal body production are described: acentriolar basal body formation (major pathway) where procentrioles are generated from a spherical aggregate of fibers; and centriolar basal body fo...

Centriole duplication is coordinated such that a single round of duplication occurs during each cell cycle. Disruption of this synchrony causes defects including supernumerary centrosomes in cancer and perturbed ciliary signaling [1-5]. To preserve the normal number of centrioles, the level, localization, and post-translational modification of centriole proteins is regulated so that, when centr...

We present mid-infrared images at 6.7 μm and 15 μm of “The Cartwheel” (AM 0035-33), the prototypical collisional ring galaxy. The observations, taken with ISOCAM, reveal the distribution of hot dust in the galaxy and its two companions in the north-east. The intensity of the Mid-IR emission from the outer star forming ring of the Cartwheel shows considerable azimuthal variation and peaks at the...

Centriole duplication is a tightly ordered process during which procentrioles are assembled in G1-S and elongate during S and G2. Here, we show that human CEP295 (Drosophila Ana1) is not essential for initial cartwheel assembly, but is required to build distal half centrioles during S and G2. Using super-resolution and immunogold electron microscopy, we demonstrate that CEP295 is recruited to t...

The process of motor learning is generally defined by four basic characteristics: 1) a set of inherent events, circumstances or changes in performing certain motor skills; 2) a direct result of exercise or experience; 3) not directly visible but estimated through performance of learned skills; 4) causes a relatively permanent change in the capacity of learned behaviours. At the beginning of art...

Dermatofibrosarcoma protuberans (DFSP) is a rare disease of dermal fibroblastic origin that accounts for less than 5% of all soft tissue sarcomas in adults. DFSP grows slowly and is an asymptomatic lesion at the initial diagnosis. Herein, we report a case of multiple pedunculated nodules as a variant of DFSP. A 47-year-old man presented with a 7-month history of multiple well-circumscribed, fir...

1. Single units and evoked potentials were recorded in dorsal cochlear nucleus (DCN) in response to electrical stimulation of the somatosensory dorsal column and spinal trigeminal nuclei (together called MSN for medullary somatosensory nuclei) and for tactile somatosensory stimuli. Recordings were from paralyzed decerebrate cats. 2. DCN principal cells (type IV units) were strongly inhibited by...