The cascade reaction of sterically hindered dipyrromethanes and formaldehyde furnished meso(10)-meso(10') linked corroles--a new type of porphyrinoid--compounds with interesting photophysical properties.

A coumarin-hemicyanine dye was reported for ratiometric fluorescent detection of SO2 derivatives HSO3(-) and SO3(2-) based on a novel addition-rearrangement cascade reaction.

Herein, we describe the creation of an artificial protein cage housing a dual-metal-tagged guest that catalyzes linear, two-step sequential cascade reaction. The consists fusion HaloTag and monomeric rhizavidin. Inside capsid, established ruthenium-catalyzed allylcarbamate deprotection reaction followed by gold-catalyzed ring-closing hydroamination led to indoles phenanthridines with overall yi...

This paper addresses the output feedback stabilization of an ODE–PDE cascade. The PDE takes form a 1-D reaction–diffusion equation. ODE enters into via Dirichlet/Neumann/Robin boundary condition. It is assumed that both and PDE, selected as Dirichlet trace, are available for control. proposed control strategy finite-dimensional observer-based controller. Under suitable structural controllabilit...

In this paper, we report development of a generalized simulation system based on ordinary differential equations for multi-cellular organisms, and results of the analysis on a Smad signal transduction cascade. The simulator implements intra-cellular and extra-cellular molecular processes, such as protein diffusion, ligand-receptor reaction, biochemical reaction, and gene expression. It simulate...

Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next enzyme in a cascade. Among many potential advantages of substrate channeling, acceleration of the total reaction rate is considered as one of the most important and self-evident. However, using a simple model, supported by stochastic simulations, we show that it is not always the case; particularl...

2-Hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis. These racemic hemiacetalic compounds are used as unconventional O-pronucleophiles in the initial oxa-Michael reaction, also leading to the formation of a single stereoisomer under a dynamic kinetic r...

We report a novel organocatalytic one-pot cascade bromination-Michael-type Friedel-Crafts alkylation dearomatization-nucleophilic rearrangement aromatization cascade process for the direct α-indolylation of unfunctionalized enals from readily available indoles with good yields and high E selectivity. The simplicity and practicality of its high efficiency for formation of a new C(sp(2))-C(sp(2))...

A novel and highly stereoselective synthesis of Z-β-enaminonitriles from azides and α,β-unsaturated nitriles is reported. The reaction proceeds via a 1,3-dipolar cycloaddition-ring cleavage-rearrangement cascade mediated by a catalytic amount of Sc(OTf)3. A plausible reaction mechanism for this process is depicted.

A new method for the synthesis of 3-arylindoles has been developed by visible light mediated dual gold/photoredox catalysis. This transformation has many features such as cascade catalysis, high efficiency, redox-neutral reaction conditions and good functional group tolerance. The reaction proceeds through the photoredox-promoted formation of an electrophilic arylgold(iii) intermediate that und...