We have previously shown that caspase-2 (Nedd-2) is required for apoptosis induced by withdrawal of trophic support from PC12 cells and sympathetic neurons. Here, we examine the relationship of caspase-2 processing and cell death to induction of caspase-3 (CPP32)-like activity in PC12 cells. Caspase-2 processing, at a site tentatively identified as D333, led to the formation of an N-terminal 37...

Houttuynia cordata Thunb. is an edible and medicinal plant that belongs to the family of Saururaceae widely distributes in Eastern Asia countries. H. have been reported as a promising anticancer agent against various cancer cells. This study was determine anti-proliferative effect extract on gastric cells using vitro experimental model. The cytotoxicity examined via 2,5-diphenyl-2H-tetrazolium ...

Abstract BACKGROUND AND AIM Chronic gut inflammation such as inflammatory bowel diseases is thought being associated with neurodegenerative in humans. The direct evidence for and the underlying mechanism of this brain-gut interaction, however, remain elusive. METHODS We used manganese-enhanced magnetic resonance imaging (MEMRI) to assess brain functional activity from awake freely moving mice. ...

Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of the underlying cellular mechanisms are lacking. The NLRP3 inflammasome genetically associated with psoriasis, its activation increasingly disease. In this study, we show that patients psoriasis exhibited higher plasma levels inflammasome-generated IL-1? IL-18, without any correlation skin lesion severi...

objective: sensory neurons in dorsal root ganglia (drg) undergo apoptosis after peripheral nerve injury. the aim of this study was to investigate sensory neuron death and the mechanism involved in the death of these neurons in cultured drg. materials and methods: in this experimental study, l5 drg from adult mouse were dissected and incubated in culture medium for 24, 48, 72 and 96 hours. fresh...

objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...