نتایج جستجو برای: caspase activity

تعداد نتایج: 1158507  

Journal: :journal of sciences islamic republic of iran 0

calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. it has been reported that this protein has an apoptotic activity in tumor cells. since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on ht29/219 and sw742 colon carcinoma and adenocarcinoma cell li...

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005
Ping Zhou Liping Qian Costantino Iadecola

Nitric oxide (NO) has been shown to inhibit apoptotic cell death by S-nitrosylation of the catalytic-site cysteine residue of caspases. However, it is not clear whether in neurons NO-mediated caspase inactivation leads to improved cell survival. To address this issue, we studied the effect of NO donors on caspase activity and cell survival in cortical neuronal culture treated with the apoptosis...

Journal: :Food Science and Technology 2022

Cancer is a disease that invades the lives of millions people each year. Chemotherapy currently most effective treatment however resulting in many adverse effects to human body. Alternative treatments are being explored overcome this obstacle. Peptides possess radical scavenging activity and bioactive properties can be advantageous prevention chronic diseases. In study, Lablab purpureus isolate...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
C J Hawkins S L Wang B A Hay

Site-specific proteases play critical roles in regulating many cellular processes. To identify novel site-specific proteases, their regulators, and substrates, we have designed a general reporter system in Saccharomyces cerevisiae in which a transcription factor is linked to the intracellular domain of a transmembrane protein by protease cleavage sites. Here, we explore the efficacy of this app...

Journal: :The Biochemical journal 2002
Ahmed A A Mohamed Orla J Jupp Helen M Anderson Alison F Littlejohn Peter Vandenabeele David J MacEwan

The activation of the extracellular signal-regulated kinases (ERKs) by tumour necrosis factor-alpha (TNF) receptors (TNFRs) is an integral part of the cytokine's pleiotropic cellular responses. Here we report differences in the caspase sensitivity and TNFR subtype activation of members of the ERK family. Inhibition in HeLa cells of caspase function by pharmacological inhibitors or the expressio...

Journal: :Jurnal Ilmiah Farmako Bahari 2022

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of acid and pepsin enzyme. The common risk factors are infection Helicobacter pylori bacteria misused NSAIDs. This review article aims describe role caspase in PUD. Methods used selection articles PubMed. Caspase a protease enzyme that plays an apoptotic inflammatory reaction can be activated dimerized or cleaved...

Journal: :iranian journal of basic medical sciences 0
chen wang department of medical market, cangzhou central hospital, hebei province, 061001, china gang wang department of cardiology, cangzhou cardiovascular research institute, cangzhou central hospital, hebei province, 061001, china hong liu department of pharmacy, general hospital of jixi mining industry group, heilongjiang province, 158100, china yun-long hou department of pharmacy, harbin medical university, heilongjiang province, 150086, china

objective(s):pharmacological studies showed that the extracts of jin yin hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. the purpose of the present study was to investigate the protective effects of caffeoylquinic acids (cqas) from jin yin hua against hydrogen ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
J Chen T Nagayama K Jin R A Stetler R L Zhu S H Graham R P Simon

Delayed neuronal death after transient cerebral ischemia may be mediated, in part, by the induction of apoptosis-regulatory gene products. Caspase-3 is a newly characterized mammalian cysteine protease that promotes cell death during brain development, in neuronal cultures, and in other cell types under many different conditions. To determine whether caspase-3 serves to regulate neuronal death ...

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