PURPOSE Progression to the castration-resistant state is the incurable and lethal end stage of prostate cancer, and there is strong evidence that androgen receptor (AR) still plays a central role in this process. We hypothesize that knocking down AR will have a major effect on inhibiting growth of castration-resistant tumors. EXPERIMENTAL DESIGN Castration-resistant C4-2 human prostate cancer...

The aim of this study was to evaluate the effect of castration and slaughter age on performance and meat quality of Holstein bulls fed a high-concentrate diet. A total of 132 animals (116 ± 3.7 kg of BW and 97 ± 2.4 d of age) were randomly allocated in 6 pens using a 3 × 3 factorial arrangement of treatments. Three castration ages [bulls, animals castrated at 3 mo (CAS3), and animals castrated ...

Following the birth of modern opera in Italy in 1600, the demand for soprano voices grew up and the prepuberal castration was carried out to preserve the young male voice into adult life. Among the castrati, Gaspare Pacchierotti was probably one of the most famous. The remains of Pacchierotti were exhumed for the first time in 2013, for a research in the reconstruction of his biological profile...

The objective of this study was to determine the effects of castration on short-term growth performance, hormone profiles, and behavior in pigs at 3, 6, 9, or 12 d of age. Ninety intact male pigs were assigned randomly to a treatment age by litter [3, 6, 9, or 12 d of age; n = 9 to 13 pigs per treatment (age) group]. Pigs within a single litter were then assigned to noncastrated (NC) or castrat...

To determine the effects of castration of calves, with or without local anesthesia, on plasma cortisol, scrotal circumference, ADG, and ADFI, 56 Friesian bulls (5.5 mo of age; mean ± SE BW = 173 ± 2 kg) were randomly assigned to each of seven treatments: 1) control (CON); 2) s.c. injection of .1 mg of a human serum albumin-GnRH conjugate with DEAEdextran adjuvant (HSA-GnRH); 3) burdizzo castrat...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For the first time in Asia, in July 2011, Korea introduced using chemical castration on sexual offenders. Under the current law, perpetrators of sexual crimes against minors aged less than 16 yr are subject to chemical castration. There have been growing cal...

Castration in weaned calves is stressful and affects profitability by reducing ADG and increasing susceptibility to disease. This study evaluated the effect of meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), on performance and health of calves received as steers compared with bull calves surgically castrated on arrival at the feedlot. British × Continental bulls (n = 145) and steers (...

Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD...

Androgens play an important role in prostate gland development and function, and have been implicated in prostate carcinogenesis. We report the regulation of the gap junctional intercellular communication gene connexin 43 (Cx43) by androgens in the prostate gland. In rat ventral prostate tissue, only trace levels of Cx43 mRNA were detected. Castration, however, resulted in a high increase in Cx...

Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, wheth...