Antigen sequence typing (ST) of FetA is part of the molecular typing scheme of Neisseria meningitidis. Among invasive meningococcal isolates from 2,201 patients in Germany, we identified 11 strains lacking the fetA gene because of deletions mediated by repeat arrays flanking the gene, i.e., Correia elements, repeat sequence 13 (RS13), and duplicated RS3. Geographic mapping and multilocus ST of ...

Purpose To perform lung image registration for reducing misregistration artifacts on three-dimensional (3D) temporal subtraction of chest computed tomography (CT) images, in order to enhance temporal changes in lung lesions and evaluate these changes after deformable image registration (DIR). Methods In 10 cases, mutual information (MI) lung mask affine mapping combined with cross-correlation...

Alleles or tightly linked genes at the soybean (Glycine max L. Merr.) Rpg1 locus confer resistance to strains of Pseudomonas syringae pv. glycinea that express the avirulence genes avrB or avrRpm1. We have previously mapped Rpg1-b (the gene specific for avrB) to a cluster of resistance genes (R genes) with diverse specificities in molecular linkage group F. Here, we describe the high-resolution...

Immunomodulatory drugs (IMiDs) are potent inhibitors of TNFand IL-1 and elevators of IL-10 production in LPS-stimulated human PBMC. They are currently in clinical trials for various diseases, including multiple myeloma, myelodysplastic syndrome, and melanoma. In the present study, we have investigated the eVects of thalidomide, CC-5013 and CC-4047 on the expression of COX-2 by stimulated PBMC. ...

Building a computationally creative system is a challenging undertaking. While such systems are beginning to proliferate, and a good number of them have been reasonably well-documented, it may seem, especially to newcomers to the field, that each system is a bespoke design that bears little chance of revealing any general knowledge about CC system building. This paper seeks to dispel this conce...

In this article, we tackle the problem of compiling cc(X) languages 9, 13] where X is an admissible constraint domain. The diiculty of this task consists in one) representing and optimising diierent domains X and two) providing an parallel and extensible execution model. A simple way to meet these demands is to provide a minimal parallel (and distributable) kernel language expressive enough to ...

Article history: Received 15 June 2015 Received in revised form 23 November 2015 Accepted 13 January 2016 Available online xxxx Recent advances in public sector open data and online mapping software are opening up new possibilities for interactive mapping in research applications. Increasingly there are opportunities to develop advanced interactive platforms with exploratory and analytical func...

Many biomolecular interactions proceed via a short-lived encounter state, consisting of multiple, lowly-populated species invisible to most experimental techniques. Recent development of paramagnetic relaxation enhancement (PRE) nuclear magnetic resonance (NMR) spectroscopy has allowed to directly visualize such transient intermediates in a number of protein-protein and protein-DNA complexes. H...