Anaplastic oligodendrogliomas (AOs) are rare brain tumors responsive to chemotherapy with procarbazine, lomustine (CCNU) and vincristine (PCV), especially when harboring 1p19q codeletion. However, with the emergence of temozolomide as an easier to administer and less toxic alternative regimen, PCV fell out of favor. Now, long-term results of two Phase III studies conceived in the 1990s, Radiati...

The effect of the 2-nitroimidazole Ro 03-8799 (8799) on the activity of 11 chemotherapeutic agents against the anaplastic MT tumour in mice has been determined by soft agar cloning. The 8799, whilst producing little cytotoxicity by itself, potentiated the cytotoxic actions of the alkylating agents melphalan and cyclophosphamide, and the nitrosoureas BCNU, CCNU and MeCCNU. This potentiation was ...

position of l-methyl-l-nitrosourea, a bone marrow toxin in animals, results in the formation of a nonmyelosuppressive but diabetogenic antitumor agent streptozotocin (10). An additional observation was the identification of a class of NO nitrosoureas and nitrosamine compounds with a R@!!4@ (C H 2)12H end group that depresses pyridine nucleotide concentrations in liver, the proposed mechanism of...

The CCNU summarization system, PUSMS (Proceeding to Using Semantic Method for Summarization), join in TAC (formerly DUC) for the first time. For the update summarization tasks, we used syntacticbased anaphora resolution and sentence compression algorithms in our system. Term significance was then obtained by frequency-related topic significance and query-related significance by obtaining cooccu...

Seizures represent a common symptom in low-grade gliomas; when uncontrolled, they significantly contribute to patient morbidity and negatively impact quality of life. Tumor location and histology influence the risk for epilepsy. The pathogenesis of tumor-related epilepsy is multifactorial and may differ among tumor histologies (glioneuronal tumors vs diffuse grade II gliomas). Gross total resec...

Newly diagnosed colon or rectal cancer should be staged using the TNM (tumor, node and distant metastasis) nomenclature to determine prognostic factors. Based on this staging, it is possible to select patients in need of adjuvant therapy following surgery. In patients with stage III colon cancer, adjuvant chemotherapy with fluorouracil and levamisole has been shown to produce a 40 percent reduc...

Results: Mean rotational femoral angle was 1.0° for cases group and 1.5° for the control group, difference was statistically significant. The difference in preoperative and postoperative HKA angles between case and control groups was found to be significant in both groups but more in cases group. The alignment of knee in cases was closer to ideal 6-degree valgus alignment than the control group...

Trials on recurrent glioblastoma have shown that bevacizumab alone is able to increase response rate on MRI, median and 6-month progression-free survival (PFS), and modestly overall survival, allowing an improvement of neurological function and a reduction of steroids. Any drug combination was not superior over bevacizumab alone. A synergistic effect of CCNU has been suggested when added to bev...