The potency of 2 nucleoside reverse transcriptase inhibitors (NRTIs) and efavirenz in patients with higher viral loads (VLs) or low CD4 cell counts remains uncertain. Virologic failure and changes in CD4 count in relation to pretreatment VL and CD4 count were evaluated in treatment-naive patients randomized to treatment groups that received 2 or 3 NRTIs with efavirenz. Over 3 years, the risk of...

background: our study aimed to determine if alteration of metabolic parameters is associated with the severity of human immunodeficiency virus (hiv) infection, progress to acquired immunodeficiency syndrome (aids), or with the type of antiretroviral treatment (art).materials and methods: in a cross-sectional study among 114 hiv infected patients, we measured hematological and biochemical parame...

BACKGROUND Oral lesions are common findings in human immunodeficiency virus (HIV) infection. The main factor associated with the development of oral lesions is damage to the immune system, specifically loss of CD4+ lymphocytes, which are involved in cell-mediated immunity. AIM This study was aimed to determine the association of oral lesions in HIV/acquired immune deficiency syndrome women pa...

BACKGROUND Recommendations that nevirapine (NVP) should be avoided in female individuals with CD4 cell counts >250 cells/microL and in male individuals with CD4 cell counts >400 cells/microL are based on findings in treatment-naive patients. It is unclear whether these guidelines also apply to treatment-experienced patients switching to NVP-based combination therapy. METHODS Patients in the A...

the purpose of this study was to determine the role of streptococcal m protein in naturally-occurring cd4+cd25+ regulatory t cells (ntregs) function and development in rheumatic heart disease in iraqi patients. streptococcus pyogenes was isolated for subsequent m protein extraction. also, peripheral blood ntregs and cd4+ t cells were isolated by using magnetic cell separation system. tissue cul...

Human immunodeficiency virus (HIV) contributes significantly to morbidity and mortality in sub-Saharan Africa, with Nigeria having the third highest burden of HIV infection globally; efforts are made to increases access to HIV/AIDS care and treatment. This has currently reached rural areas with limited manpower and laboratory evaluation capacity. This review is necessitated by the paucity of in...

Objective: This study examines the effect of the addition of IMOD, a novel multi-herbal drug to the highly active anti-retroviral therapy (HAART) regimen, on the immunological status of HIV-positive patients. Materials and Methods: A randomized two-parallel-group (HAART group versus HAART+IMOD group), pretest-posttest design was used.Sixty patients with indications for treatment with the HAART ...

This was a cross sectional study designed to evaluate the cluster of differentiation 4(CD4) count and hematological indices in HIV serodiscordant partners Jos, Nigeria. A total 20 Serodiscordant couples (40 patients) non controls) aged between 18 49 years were included study. Each participant provided 5ml venous blood sample that collected into EDTA containers for analysis CD4 indices. The foll...

INTRODUCTION There is limited data on the effects of alcohol on immunological response among persons living with HIV (PLHIV) in sub-Saharan Africa. We assessed the relationship between hazardous alcohol use and CD4+ T-cell count, among PLHIV in Uganda. METHODS PLHIV aged ≥ 18 years were enrolled in a cohort study at the Infectious diseases clinic Kampala, Uganda. Alcohol consumption was asses...