HYPOTHESIS Gluten causes symptoms, in both celiac disease and non-celiac gluten-sensitivity, by its adverse actions on the nervous system. Many celiac patients experience neurological symptoms, frequently associated with malfunction of the autonomic nervous system. These neurological symptoms can present in celiac patients who are well nourished. The crucial point, however, is that gluten-sensi...

Celiac disease is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley and rye. Although previously believed to be uncommon, celiac disease may be present in up to 1% of the general population. Celiac disease is frequently associated with many extraintestinal disord...

• Celiac plexus neurolysis (CPN)/celiac plexus block (CPB) is used to treat excruciating cancerrelated abdominal pain.1 • CPN is done via injecting 50%–100% alcohol into the celiac plexus, which is located under the diaphragm at the level of T12-L1 adjacent to the abdominal aorta and the take-off of the celiac trunk.2 • Endoscopic ultrasound guided neurolysis (EUS CPN) has been found to have 85...

Anna Sapone MD PhD, Celiac Center, Division of Gastroenterology Daniel A. Leffler MD, MS, Director of Clinical Research, Celiac Center, Director of Quality Improvement, Associate Professor of Medicine at Harvard Medical School, Division of Gastroenterology Rupa Mukherjee MD, Celiac Center, Division of Gastroenterology, Department of Medicine, Instructor in Medicine at Harvard Medical School, Be...

OBJECTIVE The objective of this evidence-based analysis was to evaluate the clinical utility of serologic testing for celiac disease in asymptomatic individuals presenting with one of the non-gastrointestinal conditions evaluated in this report. The clinical utility was based on the effects of a gluten-free diet (GFD) on outcomes specific to each of these conditions. The prevalence of celiac di...

Anandamide (AEA) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (CB1) and type-2 (CB2) cannabinoid receptors (CBR). The presence of AEA and CBR in the gastrointestinal tract highlighted their pathophysiological role in several gut diseases, including celiac disease. Here, we aimed to investigate the expression of CB...

OBJECTIVES There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international pro...

BACKGROUND The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG). METHODS We studied 6403 children with HLA haplotype DR3-DQ2 or DR4-DQ8 prospectively from birth in the United States, Finland, Germany, and Sweden. The primary end p...

BACKGROUND Celiac disease is an autoimmune disease that affects approximately 1% of the US population. Disease is characterized by damage to the small intestinal lining and malabsorption of nutrients. Celiac disease is activated in genetically susceptible individuals by dietary exposure to gluten in wheat and gluten-like proteins in rye and barley. Symptoms are diverse and include gastrointesti...