In 1508, Pope Julius II commissioned Michelangelo Buonarroti to paint the ceiling of the Cappella Sistina (Sistine Chapel) in Rome. Michelangelo labored for five years, much of it while lying on his back, to complete the task. In 1538, he was called back by Pope Paul III to add an enhancement, The Last Judgment, over the alter. This took seven more years. Michelangelo’s work on the Sistine Chap...

Cell membrane has a critical and vital role in functioning and existence of nerve cells that form central nervous system (CNS) in mammals. Disruption of nerve membrane that normally occurs following an accident injuring spinal cord is known to be the major cause of paralysis. In most occasions, spinal cord injuries are not leading to complete cut in spinal cord fibers but are known to cause cru...

miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. Its expression is frequently lost in hepatocellular carcinoma (HCC). We studied the effects of restoring miR122 expression in a distinctive cell line derived from human HCC-BCLC9 cells-with a solid stem-like cell profile, high tumor initiating ability and un...

Contact inhibition of growth is the property in vitro whose loss is most closely correlated with tumorigenicity in vivo. A contact-inhibited melanocytic cell line produces a diffusible protein-containing factor capable of restoring contact inhibition of cell division to highly malignant hamster melanocytes. Its addition to subconfluent cultures of the malignant cells is followed by the obligato...

A herd of bison has just made an extraordinary migration. The distance these animals travelled was huge—nearly 5,000 miles—and their means of transport was highly unorthodox: they fl ew. The cargo plane took some thirty of these hulking mammals from Elk Island National Park of Canada across Alaskan airspace, over the Bering Strait, and into the Republic of Yakutia. Their ultimate destination: t...

Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by encoding assembled group-specific antigen sequence and the envelope Syncytin-1. Syncytin-1 constitutively fusogenic forms large multinucleated cell fusions when overexpressed. Consequently, immunising humans with a can lead to formation o...