The overall function of a cell is determined by its contingent of active signal transduction cascades interacting on multiple levels with metabolic pathways, cytoskeletal organization, and regulation of gene expression. Much work has been devoted to analysis of individual signalling cascades interacting with unique cellular targets. However, little is known about how cells integrate information...

Communication among cells was paramount to the evolutionary increase in cell type diversity and, ultimately, the origin of large body size. Across the diversity of Metazoa, there are only few conserved cell signalling pathways known to orchestrate the complex cell and tissue interactions regulating development; thus, modification to these few pathways has been responsible for generating diversi...

C-type lectin-like CD161, a class II transmembrane protein, is surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was more frequently on gluten-reactive CD4 + compared to other memory isolated from the same tissue compartment. putative co-signalling molecule that proposed act as co-stimulatory in context of signalling through TCR, but contradicting results were publis...

Alin Bostan, Shaoshi Chen, Frédéric Chyzak, Ziming Li, Guoce Xin INRIA, Palaiseau, 91120, (France) Department of Mathematics, NCSU, Raleigh, 27695-8025, (USA) KLMM, AMSS, Chinese Academy of Sciences, Beijing 100190, (China) Department of Mathematics, Capital Normal University, Beijing 100048, (China) [email protected], {alin.bostan, frederic.chyzak}@inria.fr [email protected], [email protected]

The function and efficiency of cell signalling pathways are very dependent on their organization both in space and time. With regard to spatial organization, signalling components are highly organized with respect to their cellular location and how they transmit information from one region of the cell to another. This spatial organization of signalling pathways depends on the molecular interact...

Simplifying the process greatly, signalling proteins known as kinases can be unphosphorylated (inactive) or phosphorylated (active). Cell signalling uses the phosphorylation machinery to pass messages from the exterior of the cell to the interior where they will be acted upon. This message passing is achieved via a relay of kinases and other proteins (the signalling pathway), which can be thoug...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping researchers promote themselves alongside their papers. Boris Sieber and Fangfang Lu are co-first on ‘ iRhom2 regulates ERBB signalling to KRAS-driven tumour growth lung cancer cells’, JCS. postdoc lab Sophie Martin at University Lausanne, Switzerland, investigating ...