PURPOSE The purposes of this study were to evaluate the spatial distribution of neovessels versus mature vessels in both human retinoblastoma (RB) and LH(BETA)T(AG) tumors, assess similarities and differences between the animal model and the human RB specimens, and determine whether vessel maturation is associated with risk factors for metastasis. METHODS Immunohistochemical analyses were per...

The article considers two paradigms of the center-periphery interaction in mixed and multiethnic systems. historical examples show peculiarities colonial paradigm where peripheral culture is suppressed displaced by center (metropolis). eparchial based on cross-cultural enrichment between provinces. Within final decades 20th century, principle was replaced “cultural colonization” global scale. A...

A typical open field consists of a square enclosure, bounded by four straight walls joined by identical corners. For decades behavioral researchers have used the open center and more sheltered perimeter of such fields to examine the effects of drugs, sex differences, and illumination on the behavioral expression of fear and anxiety. The present study "reversed" the relative security of the cent...

BACKGROUND The aim of this study was to determine the regional heterogeneity and clinicopathological significance of microRNA-21 (miR-21) in advanced colorectal cancer (CRC) patients with distant metastasis. METHODS miR-21 expression was investigated by using locked nucleic acid- fluorescence in situ hybridization in the center and periphery of the primary cancer and in distant metastasis fro...

Abstract This article analyzes the creation of value in (semi-)peripheral fields, using interview (N=94) and ethnographic data creatives, models cultural intermediaries Polish Dutch fashion. Drawing on field theory center-periphery theories we show that these peripheral fields have a distinct structure— worlds —marked by dependence foreign centers for goods, standards consecration, which actors...

OBJECTIVE Laminar shear stress is atheroprotective for endothelial cells (ECs), whereas nonlaminar, disturbed, or oscillatory shear stress correlates with development of atherosclerosis and neointimal hyperplasia. The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared. METHODS ECs were exposed to orbital shear stress with an orbital shaker...