Among the methods available to reduce water production, injecting a gelling system composed of a polymer and a crosslinker has been widely used. In this work, a hydrogel was prepared by crosslinking of an aqueous solution containing hexamethylenetetramine (HMTA) as crosslinker, hydrochloric acid (HCl) as an activator, and the co-polymer of 2-acrylamido-2methyl-propanesulfonic-acid sodium salt (...

Background: Amongst the methods that remove heavy metals from environment, biosorption approaches have received increased attention because of their environmentally friendly and cost-effective feature, as well as their superior performances. Methods: In the present study, we investigated the ability of a surface-engineered Escherichia coli, carrying the cyanobacterial metallothionein on the cel...

Isoniazid (INH) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. This composite electrode exhibited 4-fold higher oxidation of INH, in accordance with peak densities, than the bare gold electrode. It was used the central compo...

Methotrexate (MTX) being the widely used biologic agent is used to treat severe and/or disabling psoriasis but precipitates various side effects on oral therapy. Encapsulating methotrexate in flexible liposomes for delivery through skin could lead to better therapeutic action and reduce side effects. In order to screen out the various factors during liposome formulation development, Plackett Bu...

The preset response surface methodology (RSM) designs are commonly used in a wide range of process and design optimization applications. Although they offer ease of implementation and good performance, they are not sufficiently adaptive to reduce the required number of experiments and thus are not cost effective for applications with high cost of experimentation. We propose an efficient adaptiv...

Objective: The present study’s objective was to apply a central composite design develop the simvastatin-loaded nanosponge formulation improve its oral bioavailability. Methods: With help of expert (State-Ease version 13.0.1), selected for nanosponges by using defined concentration Eudragit L-100 (X1) and PVA (X2) as independent variables particle size (Y1), percent (%) entrapment efficiency (E...