The symptomatology and pathology of lesions of the brain following the injection of thromboplastic substance, as has been pointed out,10 cannot be attributed exclusively to thrombi or emboli in the cerebral vessels. The quick recovery from unconsciousness and the absence of thrombi in the cerebral vessels as well as the general nature of the lesions indicate rather that a temporary disturbance ...

Human apolipoprotein E (apoE) has 3 isoforms: apoE2, apoE3, and apoE4. APOE4 is a major genetic risk factor for Alzheimer disease and is associated with dementia in Down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. While apoE4 can induce neuropathology by participating in various cellular and molecular pathways,...

OBJECTIVE Previously, we documented association between CSF circulation and transcranial-Doppler derived autoregulation in non-shunted patients suffering from hydrocephalus. In the present study we sought to investigate the relationship between the resistance to CSF outflow and pressure-reactivity both in shunted and non-shunted NPH patients. MATERIAL AND METHODS Sixty-eight patients (47 non-...

BACKGROUND AND PURPOSE Brain temperature is critical for homeostasis, relating intimately to cerebral perfusion and metabolism. Cerebral thermometry is historically challenged by the cost and invasiveness of clinical and laboratory methodologies. We propose the use of noninvasive MR thermometry in patients with cerebrovascular disease, hypothesizing the presence of a measurable brain thermal re...

Blood flow and vasodilatory responses are altered by age in a number of vascular beds, including the cerebral circulation. To test the role of prostaglandins as regulators of cerebral vascular function, we examined cerebral vasodilator responses to CO(2) (cerebrovascular reactivity) in young (26 ± 5 yr; 6 males/6 females) and older (65 ± 6 yr, 5 males/5 females) healthy humans before and after ...

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frequency of common etiologies of adult onset epilepsy is different in various studies. the aim of this study is to evaluate the frequency of common ‎etiologies of late adult onset epilepsies. ‎ all patients referred to razi and imam khomeini hospitals ‎in the year 2003 with at least two seizure attacks beginning after age of 50 were evaluated. in the majority of cases neuroimaging, electroence...

We describe 2 children with cerebrovascular events caused by emboli from left atrial myxomas and review 7 other pediatric cases from the literature. Transient cutaneous eruptions involving the extremities preceded the cerebrovascular events and were most likely attributable to fragmentation of the atrial tumor with peripheral embolization. Our first case demonstrates the more common presentatio...